Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.
about
PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organizationThe TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodelingPak1 and PIX regulate contact inhibition during epithelial wound healingPaxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathwayHuman immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant productionCofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formationEndogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathwayThe plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand bindingp21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BADThe semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent mannerPhosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnoverCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteinsPhosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphologyCofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cellsThe Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteinsB-Raf and Raf-1 are regulated by distinct autoregulatory mechanismsMolecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitationsPAK as a therapeutic target in gastric cancerPAK1 negatively regulates the activity of the Rho exchange factor NET1Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formationDeficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytesRac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreadingTemporal and spatial distribution of activated Pak1 in fibroblastsRho GTPases and their effector proteinsDirect binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2.The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL).A Rac-cGMP signaling pathway.The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakBIdentification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain."UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infectionReciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysisThe Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions
P2860
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P2860
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation.
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@ast
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@en
type
label
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@ast
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@en
prefLabel
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@ast
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@en
P2093
P356
P1476
Differential effects of PAK1-a ...... ts on cytoskeletal regulation.
@en
P2093
P304
28191-28198
P356
10.1074/JBC.273.43.28191
P407
P577
1998-10-01T00:00:00Z