Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
about
Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesThe FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomesCaveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complexAssembly and Turnover of Caveolae: What Do We Really Know?Ring of Change: CDC48/p97 Drives Protein Dynamics at ChromatinCardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function.ESCRT-III controls nuclear envelope reformation.The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 MutantsCdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Mutations in the Human AAA+ Chaperone p97 and Related DiseasesAltered cofactor regulation with disease-associated p97/VCP mutationsControl of p97 function by cofactor bindingStructure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPaseProtection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signalingSystematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell receptor α retro-translocationAltered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathyGenome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes.The influence of a caveolin-1 mutant on the function of P-glycoprotein.Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPaseStructural and functional deviations in disease-associated p97 mutants.The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1.Structure and function of the AAA+ ATPase p97/Cdc48p.Role of p97/VCP (Cdc48) in genome stability.p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism that Increases the Enzyme's ATPase Activity.The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNPmTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo.A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry.TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia.
P2860
216231f5d4e59fd0a7be250854ba7ee127b453b042d456fd54d5d2e92ecb96d1136839b1542a024c62639e360257d141248c91a607f4b426c432185f656d042c6f0318a9f6b723311023e611bc6d3695697a45d3e07a07c65a44e686a4e8fc009ed705b97355fd3fcf5ae880619e4f6ba5949fbcff1da5247f3f8877c67462c5319ece192750e262c331825dbe09606ec49619ccd4291d13576cca6d1a75e967
P248
Q21285051-FA80094A-79FC-4166-84D9-3676E79C1B6EQ24314869-8B66B873-B71C-4224-BDF7-E00C3F4A64CBQ24337689-B3AB5846-14A9-41B0-AB50-C821F8FDD7AEQ26742079-87F64EAB-EA21-4BA4-8D89-47AC1A4C3113Q26747328-499BB1BD-4987-419A-A58B-4D52A258A6EFQ27303589-2EA57B0C-6A2E-4790-A9FC-E41C613D1E28Q27316488-E71715CF-394E-469A-BFA3-D69220030662Q27673802-E5B39736-BDB5-4BCA-984C-5C5A81AF8FCBQ27680547-F3BB13C3-3760-4D47-A25F-A64C181C2C61Q27939735-5B0260ED-230F-42F0-BA87-DC7677BCB023Q28080241-B5EBF5C0-5AC0-41D0-89CB-1504BDDE86CDQ28258936-C2802F7D-8F32-46E0-BD41-23CC6894426BQ28266780-DE66EB03-62F2-452F-BD66-B32667A2F7CFQ28283214-F3B3C0A0-077C-48CF-9E31-C413A8A94D2BQ28544687-6BE587F1-5C7F-458A-AA0E-6C6801466338Q29871526-597827B9-B70A-4616-90BD-A0C50BF079C8Q30274624-125EFB81-8FF2-4396-9803-00D5537073C9Q30274646-B201D6C1-1A34-47CF-9D78-86228476EECCQ30380374-7861B818-9181-4A12-AF1B-B016C873E5BCQ30540665-605D9730-F161-4366-9B8E-EF5E2732F097Q33790385-D3E93288-AAE3-4593-9563-CC3575442E80Q34178673-717BE6C1-5E57-4226-9EB3-D22FB64E849FQ34226618-24D9DBB5-67CA-412B-B135-BDAEAD9060FCQ35022480-BE38106F-CE5F-4F83-B376-1F7EDD0A01EEQ35856248-F8047904-59E8-4F82-9891-446120FAE58EQ36208116-CB6D3FA6-6ED6-4731-AD17-B7E1A5F819BEQ36542701-0F5CBF6D-1903-4BB5-B427-223F2751CB1AQ36549348-1A4708C5-2E72-462D-8890-4DE85907007AQ36666294-BFA3FD0F-9F7C-458F-8979-C6AE4D258ACBQ36677811-ED94D26D-B3F8-4540-BB33-FAB97AEF0ECBQ36744845-DE640198-5F5E-4072-B966-F920C60F6C1FQ36767612-E9572CE5-CDD3-4BDF-8B5B-958D7BE593F5Q36804013-D4A17F76-D8A4-47A0-8E59-BA6EFCD9A6CEQ36827995-8C64258D-D7F3-42EB-AB13-6C56723ECDE3Q36850433-200E82E7-8136-480C-837A-DFE40B8A5F8CQ36853801-AE07E667-BA4B-4A72-A2FE-EF5869EB4AE3Q37380178-BDA7F267-2489-4E57-A15A-82787B8EF9F4Q37404484-1456012E-3608-4991-A0F4-F698888E50C9Q37576241-1CD84442-746A-45EB-A469-ACF7DE484997Q37621660-EEF3ADD4-A089-4D30-A7E1-2592051027D6
P2860
Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@ast
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@en
type
label
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@ast
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@en
prefLabel
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@ast
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@en
P2093
P2860
P50
P921
P356
P1433
P1476
Endolysosomal sorting of ubiqu ...... aired by VCP disease mutations
@en
P2093
Caleb Lusk
Conrad C Weihl
Danilo Ritz
Houkeun Lee
Matthias Gstaiger
Monika Bug
Philipp Kirchner
Robert H Baloh
Sabina Schütz
P2860
P2888
P304
P356
10.1038/NCB2301
P577
2011-08-07T00:00:00Z
P5875
P6179
1003185215