Imbalances in p97 co-factor interactions in human proteinopathy
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SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myelomaThe UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradationThe tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteinsExome sequencing reveals VCP mutations as a cause of familial ALSInsights into muscle degeneration from heritable inclusion body myopathiesCardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function.The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 MutantsMutations in the Human AAA+ Chaperone p97 and Related DiseasesNucleotide-dependent conformational changes of the AAA+ ATPase p97 revisitedThe general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactorsEmerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemAltered cofactor regulation with disease-associated p97/VCP mutationsControl of p97 function by cofactor bindingThe p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteinsSystematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutationsProtein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strainsCellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cellsGlobal gene profiling of VCP-associated inclusion body myopathy.Inhibitors of the AAA+ chaperone p97Structural and functional deviations in disease-associated p97 mutants.Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.Point-of-care test for cervical cancer in LMICs.A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions.The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.Aggrephagy: selective disposal of protein aggregates by macroautophagy.Cdc48: a swiss army knife of cell biology.Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.
P2860
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P2860
Imbalances in p97 co-factor interactions in human proteinopathy
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Imbalances in p97 co-factor interactions in human proteinopathy
@ast
Imbalances in p97 co-factor interactions in human proteinopathy
@en
Imbalances in p97 co-factor interactions in human proteinopathy
@en-gb
Imbalances in p97 co-factor interactions in human proteinopathy
@nl
type
label
Imbalances in p97 co-factor interactions in human proteinopathy
@ast
Imbalances in p97 co-factor interactions in human proteinopathy
@en
Imbalances in p97 co-factor interactions in human proteinopathy
@en-gb
Imbalances in p97 co-factor interactions in human proteinopathy
@nl
prefLabel
Imbalances in p97 co-factor interactions in human proteinopathy
@ast
Imbalances in p97 co-factor interactions in human proteinopathy
@en
Imbalances in p97 co-factor interactions in human proteinopathy
@en-gb
Imbalances in p97 co-factor interactions in human proteinopathy
@nl
P2860
P3181
P356
P1433
P1476
Imbalances in p97 co-factor interactions in human proteinopathy
@en
P2093
Alexander Buchberger
Vanesa Fernández-Sáiz
P2860
P304
P3181
P356
10.1038/EMBOR.2010.49
P407
P577
2010-06-01T00:00:00Z