Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
about
Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brainHuman APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer modelGenetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathwaysImportance of Apolipoprotein A-I in Multiple SclerosisThe low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's diseaseApolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer diseaseDysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseasesThe genetics of Alzheimer diseaseDeletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficitsIVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathologyApolipoprotein E and Alzheimer disease: risk, mechanisms and therapySortilin, a novel APOE receptor implicated in Alzheimer diseaseLow-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytesMicroglia as a critical player in both developmental and late-life CNS pathologies.Phagocytic clearance in neurodegeneration.Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice.Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal traffickingApolipoprotein E epsilon4 does not modulate amyloid-β-associated neurodegeneration in preclinical Alzheimer disease.Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis.Clocks and Cholesterol: Co-agonists in Cardiovascular Disease?An expanded role for neuroimaging in the evaluation of memory impairment.Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesisLack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trialsBlocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.Expression and regulation of a low-density lipoprotein receptor exon 12 splice variant.Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms.LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses.Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's diseaseGi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.Neuronal activity regulates the regional vulnerability to amyloid-β deposition.PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal proteaseRole of SFRS13A in low-density lipoprotein receptor splicing
P2860
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P248
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P2860
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Overexpression of low-density ...... extracellular A beta clearance
@ast
Overexpression of low-density ...... extracellular A beta clearance
@en
type
label
Overexpression of low-density ...... extracellular A beta clearance
@ast
Overexpression of low-density ...... extracellular A beta clearance
@en
prefLabel
Overexpression of low-density ...... extracellular A beta clearance
@ast
Overexpression of low-density ...... extracellular A beta clearance
@en
P2093
P2860
P921
P1433
P1476
Overexpression of low-density ...... extracellular A beta clearance
@en
P2093
David M Holtzman
Hong Jiang
Jacob M Basak
Maia Parsadanian
Stephanie M Mason
Steven M Paul
P2860
P304
P356
10.1016/J.NEURON.2009.11.013
P407
P577
2009-12-01T00:00:00Z