Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice - Wikidata - awgldk - TriplyDB

Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice

Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice

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AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21 Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.Challenging of AS160/TBC1D4 Alters Intracellular Lipid milieu in L6 Myotubes Incubated With Palmitate.Effect of resistance exercise under conditions of reduced blood insulin on AMPKα Ser485/491 inhibitory phosphorylation and AMPK pathway activation.The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.AMPK/AS160 mediates tiliroside derivatives-stimulated GLUT4 translocation in muscle cells.Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

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P2860

Rab GAPs AS160 and Tbc1d1 play nonredundant roles in the regulation of glucose and energy homeostasis in mice

http://www.wikidata.org/entity/Q30277981

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2015 nî lūn-bûn

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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Rab GAPs AS160 and Tbc1d1 play ...... and energy homeostasis in mice

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Rab GAPs AS160 and Tbc1d1 play ...... and energy homeostasis in mice

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Rab GAPs AS160 and Tbc1d1 play ...... and energy homeostasis in mice

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Rab GAPs AS160 and Tbc1d1 play ...... and energy homeostasis in mice

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Rab GAPs AS160 and Tbc1d1 play ...... and energy homeostasis in mice

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P356

AJPENDO.00342.2015

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American Journal of Physiology - Endocrinology and Metabolism

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Rab GAPs AS160 and Tbc1d1 play ...... and energy homeostasis in mice

@en

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Natalie N Walker

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Stefan R Hargett

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Susanna R Keller

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P2860

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking

Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice

Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis.

Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation.

TBC proteins: GAPs for mammalian small GTPase Rab?

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation.

TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition.

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10.1152/AJPENDO.00342.2015

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