Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl - Wikidata - awgldk - TriplyDB

Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

http://www.wikidata.org/entity/Q30305582

about

Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2 RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo Urokinase receptor and resistance to targeted anticancer agents Possible physiological role of H19 RNA The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motility Mechanism of Focal Adhesion Kinase Mechanosensing LRP: a multifunctional scavenger and signaling receptor Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth.Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling.Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells.Breast cancer and metabolic syndrome linked through the plasminogen activator inhibitor-1 cycle Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis.Epigenetic upregulation of urokinase plasminogen activator promotes the tropism of mesenchymal stem cells for tumor cells.Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor.The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis.Aggregated low-density lipoprotein induce impairment of the cytoskeleton dynamics through urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor in human vascular smooth muscle cell.Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.Urokinase upregulates matrix metalloproteinase-9 expression in THP-1 monocytes via gene transcription and protein synthesis Role of myofibroblasts at the invasion front.RNAi-mediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth.Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling.Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells.A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen Role of plasminogen activator inhibitor-1 in urokinase's paradoxical in vivo tumor suppressing or promoting effects Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.Focal adhesion kinase overexpression and its impact on human osteosarcoma.The inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA-uPAR complex and inhibiting its signaling and internalization.Inhibition of Grb2-mediated activation of MAPK signal transduction suppresses NOR1/CB1954-induced cytotoxicity in the HepG2 cell line Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.Suppression of uPA and uPAR blocks radiation-induced MCP-1 mediated recruitment of endothelial cells in meningioma.Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism.Polymorphonuclear cells stimulate the migration and metastatic potential of rat sarcoma cells.Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2.An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia.Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.The receptor for urokinase-type plasminogen activator regulates fibronectin matrix assembly in human skin fibroblasts.Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation.Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.

P2860

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P2860

Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

http://www.wikidata.org/entity/Q30305582

description

2000 nî lūn-bûn

@nan

2000 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հունիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Urokinase-type plasminogen act ...... ociation of GRB2/Sps-Shc compl

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Urokinase-type plasminogen act ...... ociation of GRB2/Sps-Shc compl

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Urokinase-type plasminogen act ...... ociation of GRB2/Sps-Shc compl

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Journal of Biological Chemistry

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Urokinase-type plasminogen act ...... ociation of GRB2/Sps-Shc compl

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Catling AD

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Gonias SL

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Nguyen DH

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scholarly article

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10.1074/JBC.M909575199

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25

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275

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