The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics.
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p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2Modulation of TRPC5 cation channels by halothane, chloroform and propofolOncogenic potential of TASK3 (Kcnk9) depends on K+ channel functionMolecular targets underlying general anaesthesiaTwo-pore Domain Potassium Channels in AstrocytesThe acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by HistamineThe role of pH-sensitive TASK channels in central respiratory chemoreception.Convergent and reciprocal modulation of a leak K+ current and I(h) by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones.Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neuronsCentral respiratory chemoreception.Anesthetic activation of central respiratory chemoreceptor neurons involves inhibition of a THIK-1-like background K(+) current.Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anestheticsSubunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice.Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact.Monitoring the depth of anaesthesia.Task2 potassium channels set central respiratory CO2 and O2 sensitivity.Membrane potential depolarization as a triggering mechanism for Vpu-mediated HIV-1 release.Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.Functional expression of TASK-1/TASK-3 heteromers in cerebellar granule cells.Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK.Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity.Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept.Carvedilol targets human K2P 3.1 (TASK1) K+ leak channelsThe Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.Serotonin nerve terminals in the dorsomedial medulla facilitate sympathetic and ventilatory responses to hemorrhage and peripheral chemoreflex activation.TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.Isoflurane abolishes spontaneous firing of serotonin neurons and masks their pH/CO₂ chemosensitivity.Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels.Isoflurane causes concentration-dependent inhibition of medullary raphé 5-HT neurons in situ.Serotonergic modulation of inspiratory hypoglossal motoneurons in decerebrate dogsEffects of general anesthetics on visceral pain transmission in the spinal cord.Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.Medullary serotonin neurons and central CO2 chemoreception.A Role for K2P Channels in the Operation of Somatosensory NociceptorsSerotonin neurons and central respiratory chemoreception: where are we now?Neuromodulation of neurons and synapses.
P2860
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P2860
The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics.
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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name
The TASK-1 two-pore domain K+ ...... cts of inhalation anesthetics.
@ast
The TASK-1 two-pore domain K+ ...... cts of inhalation anesthetics.
@en
type
label
The TASK-1 two-pore domain K+ ...... cts of inhalation anesthetics.
@ast
The TASK-1 two-pore domain K+ ...... cts of inhalation anesthetics.
@en
prefLabel
The TASK-1 two-pore domain K+ ...... cts of inhalation anesthetics.
@ast
The TASK-1 two-pore domain K+ ...... cts of inhalation anesthetics.
@en
P2093
P1476
The TASK-1 two-pore domain K+ ...... ects of inhalation anesthetics
@en
P2093
P304
P356
10.1523/JNEUROSCI.20-17-06347.2000
P407
P577
2000-09-01T00:00:00Z