Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing.
about
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid raftsInhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseRequirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseCell surface binding and internalization of aβ modulated by degree of aggregationThe many substrates of presenilin/γ-secretase.Neuronal membrane cholesterol loss enhances amyloid peptide generation.Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes.
P2860
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P2860
Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Endosomal sorting of amyloid p ...... fluences secretase processing.
@ast
Endosomal sorting of amyloid p ...... fluences secretase processing.
@en
type
label
Endosomal sorting of amyloid p ...... fluences secretase processing.
@ast
Endosomal sorting of amyloid p ...... fluences secretase processing.
@en
prefLabel
Endosomal sorting of amyloid p ...... fluences secretase processing.
@ast
Endosomal sorting of amyloid p ...... fluences secretase processing.
@en
P2860
P1433
P1476
Endosomal sorting of amyloid p ...... fluences secretase processing.
@en
P2093
Daugherty BL
P2860
P304
P356
10.1034/J.1600-0854.2001.21206.X
P577
2001-12-01T00:00:00Z