Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network
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PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinSorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complexCellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel diseaseModulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationTrafficking regulation of proteins in Alzheimer's diseaseComplex regulation of γ-secretase: from obligatory to modulatory subunitsProtection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloidThe Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseConstitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzymeMunc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processingAsynchronous evolutionary origins of Aβ and BACE1Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing.Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers.The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminalsTargeting Abeta and tau in Alzheimer's disease, an early interim reportThe secretases: enzymes with therapeutic potential in Alzheimer disease.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.An overview of APP processing enzymes and products.Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway.Evaluation of BACE1 Silencing in Cellular ModelsRegulation of APP cleavage by alpha-, beta- and gamma-secretases.The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortexDual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ productionSecretases as therapeutic targets for the treatment of Alzheimer's disease.Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.Regulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal β-amyloid fragment.A common BACE1 polymorphism is a risk factor for sporadic Creutzfeldt-Jakob diseaseSecretases as targets for drug design in Alzheimer's disease.Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice.PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft traffickingP2Y receptors in Alzheimer's disease.Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system.Polyphenols as therapeutic molecules in Alzheimer's disease through modulating amyloid pathways.
P2860
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P2860
Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@ast
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@en
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@nl
type
label
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@ast
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@en
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@nl
altLabel
Protein Kinase C-dependent -S ...... ein in the Trans-Golgi Network
@ast
Protein Kinase C-dependent -S ...... ein in the Trans-Golgi Network
@en
prefLabel
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@ast
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@en
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@nl
P2093
P3181
P356
P1476
Protein Kinase C-dependent -S ...... ein in the Trans-Golgi Network
@en
Protein kinase C-dependent alp ...... ein in the trans-golgi network
@en
P2093
D M Skovronsky
D. B. Moore
D. M. Skovronsky
M. E. Milla
R. W. Doms
V. M.- Y. Lee
P304
P3181
P356
10.1074/JBC.275.4.2568
P407
P577
2000-01-28T00:00:00Z