A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein.
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The remarkable transport mechanism of P-glycoprotein: a multidrug transporter.Multiple Drug Transport Pathways through Human P-Glycoprotein.Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism.Catalytic and transport cycles of ABC exporters.Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approachExploring the P-glycoprotein binding cavity with polyoxyethylene alkyl ethers.Single liposome analysis of peptide translocation by the ABC transporter TAPL.P-glycoprotein-ATPase modulation: the molecular mechanisms.Synthesis and study of new paramagnetic and diamagnetic verapamil derivatives.The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely togetherAdenylate kinase activity in ABC transporters.On the origin of large flexibility of P-glycoprotein in the inward-facing stateHuman P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.Na⁺-substrate coupling in the multidrug antiporter norm probed with a spin-labeled substrate.NMR and EPR studies of membrane transporters.Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.Unidirectional Transport Mechanism in an ATP Dependent Exporter.The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoproteinCysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesisEpigallocatechin-3-gallate suppressed the over-expression of HSP 70 and MDR1 induced by heat shock in SGC 7901.The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.Disulfide cross-linking analysis shows that transmembrane segments 5 and 8 of human P-glycoprotein are close together on the cytoplasmic side of the membrane.A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein.Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein.Interfacial enzyme kinetics of a membrane bound kinase analyzed by real-time MAS-NMR.P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state.Val133 and Cys137 in transmembrane segment 2 are close to Arg935 and Gly939 in transmembrane segment 11 of human P-glycoprotein.EPR studies of intermolecular interactions and competitive binding of drugs in a drug-BSA binding model.Physiological concentrations of albumin favor drug binding.Single-molecule theory of enzymatic inhibition.
P2860
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P2860
A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@ast
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@en
type
label
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@ast
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@en
prefLabel
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@ast
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@en
P2860
P356
P1476
A novel electron paramagnetic ...... g transport by P-glycoprotein.
@en
P2093
Hiroshi Omote
Marwan K Al-Shawi
P2860
P304
45688-45694
P356
10.1074/JBC.M206479200
P407
P577
2002-09-19T00:00:00Z