The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together
about
Multiple Drug Transport Pathways through Human P-Glycoprotein.Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1)Equilibrated atomic models of outward-facing P-glycoprotein and effect of ATP binding on structural dynamics.Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance.Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein.Factors that limit positron emission tomography imaging of p-glycoprotein density at the blood-brain barrier.Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expressionHydrolysis at one of the two nucleotide-binding sites drives the dissociation of ATP-binding cassette nucleotide-binding domain dimers.Analyses of conformational states of the transporter associated with antigen processing (TAP) protein in a native cellular membrane environment.Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoproteinCysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination.Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions.Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein.Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.Dissecting the Forces that Dominate Dimerization of the Nucleotide Binding Domains of ABCB1.
P2860
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P2860
The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
The ATPase activity of the P-g ...... ns are linked closely together
@ast
The ATPase activity of the P-g ...... ns are linked closely together
@en
type
label
The ATPase activity of the P-g ...... ns are linked closely together
@ast
The ATPase activity of the P-g ...... ns are linked closely together
@en
prefLabel
The ATPase activity of the P-g ...... ns are linked closely together
@ast
The ATPase activity of the P-g ...... ns are linked closely together
@en
P2093
P2860
P356
P1476
The ATPase activity of the P-g ...... ns are linked closely together
@en
P2093
David M Clarke
M Claire Bartlett
Michael R Detty
P2860
P304
26806-26816
P356
10.1074/JBC.M112.376202
P407
P50
P577
2012-06-14T00:00:00Z