Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
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CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complexThe ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokineThe human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membraneSignaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNFSolution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complexInsights into cytokine-receptor interactions from cytokine engineeringThe existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogueSignaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha componentRapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factorSoluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responsesA ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.IL-6 type cytokine receptor complexes: hexamer, tetramer or both?Receptor recognition by gp130 cytokines.Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptorgp130 receptor ligands as potential therapeutic targets for obesity.Interleukin-6 trans-signalling in chronic inflammation and cancer.LIF in the regulation of T-cell fate and as a potential therapeutic.Targeting gp130 to prevent inflammation and promote insulin action.Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor.Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation.Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptorSortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor.Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor.The balance of Interleukin (IL)-6, IL-6:soluble IL-6 receptor (IL-6R) and IL-6:sIL-6R:sgp130 complexes allows simultaneous classic and trans-signalingStructure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation.Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6
P2860
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P2860
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Receptor recognition sites of ...... ophic factor to interleukin-6.
@ast
Receptor recognition sites of ...... ophic factor to interleukin-6.
@en
type
label
Receptor recognition sites of ...... ophic factor to interleukin-6.
@ast
Receptor recognition sites of ...... ophic factor to interleukin-6.
@en
prefLabel
Receptor recognition sites of ...... ophic factor to interleukin-6.
@ast
Receptor recognition sites of ...... ophic factor to interleukin-6.
@en
P2093
P2860
P356
P1476
Receptor recognition sites of ...... ophic factor to interleukin-6.
@en
P2093
Grötzinger J
Lelièvre E
Myer zum Büschenfelde KH
Müllberg J
Rose-John S
P2860
P304
11859-11867
P356
10.1074/JBC.274.17.11859
P407
P577
1999-04-01T00:00:00Z