Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain. Zn(II) release activates DDAH-1.
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Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and DevelopmentPacked red blood cells are an abundant and proximate potential source of nitric oxide synthase inhibitionZn(II)-free dimethylargininase-1 (DDAH-1) is inhibited upon specific Cys-S-nitrosylationZinc-binding cysteines: diverse functions and structural motifs.Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening.Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase.How to control NO production in cells: N(omega),N(omega)-dimethyl-L-arginine dimethylaminohydrolase as a novel drug target.A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.Inhibitory zinc sites in enzymes.Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats.Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.Contribution of whole blood to the control of plasma asymmetrical dimethylarginine.Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.
P2860
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P2860
Structural and functional characterization of the Zn(II) site in dimethylargininase-1 (DDAH-1) from bovine brain. Zn(II) release activates DDAH-1.
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2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural and functional char ...... (II) release activates DDAH-1.
@ast
Structural and functional char ...... (II) release activates DDAH-1.
@en
type
label
Structural and functional char ...... (II) release activates DDAH-1.
@ast
Structural and functional char ...... (II) release activates DDAH-1.
@en
prefLabel
Structural and functional char ...... (II) release activates DDAH-1.
@ast
Structural and functional char ...... (II) release activates DDAH-1.
@en
P2093
P2860
P356
P1476
Structural and functional char ...... (II) release activates DDAH-1.
@en
P2093
P2860
P304
40449-40456
P356
10.1074/JBC.M104056200
P407
P577
2001-08-23T00:00:00Z