Energy functions for protein design: adjustment with protein-protein complex affinities, models for the unfolded state, and negative design of solubility and specificity.
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A smoothed backbone-dependent rotamer library for proteins derived from adaptive kernel density estimates and regressionsComputational Redesign of the SHV-1 β-Lactamase/β-Lactamase Inhibitor Protein InterfaceComputer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet DesignStructural and Biochemical Characterization of the Interaction between KPC-2 β-Lactamase and β-Lactamase Inhibitor Protein,Computational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone TemplateComputational protein design: the Proteus software and selected applications.Computational protein design: validation and possible relevance as a tool for homology searching and fold recognitionNeEMO: a method using residue interaction networks to improve prediction of protein stability upon mutation.Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design.Computational approaches to study the effects of small genomic variations.In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity.Protein structure modelling and evaluation based on a 4-distance description of side-chain interactionsAn Evolution-Based Approach to De Novo Protein Design.Prediction of protein mutation effects based on dehydration and hydrogen bonding - A large-scale study.Designing specific protein-protein interactions using computation, experimental library screening, or integrated methodsFine mapping of the sequence requirements for binding of beta-lactamase inhibitory protein (BLIP) to TEM-1 beta-lactamase using a genetic screen for BLIP function.Four distances between pairs of amino acids provide a precise description of their interactionProtein thermostability calculations using alchemical free energy simulationsPredicting changes in protein thermostability brought about by single- or multi-site mutationsA nucleosomal approach to inferring causal relationships of histone modifications.Experimental library screening demonstrates the successful application of computational protein design to large structural ensemblesThe contribution of coevolving residues to the stability of KDO8P synthase.Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnosticsEnhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.A fast and precise approach for computational saturation mutagenesis and its experimental validation by using an artificial (βα)8-barrel protein.Sequence optimization and designability of enzyme active sites.DBAC: a simple prediction method for protein binding hot spots based on burial levels and deeply buried atomic contacts.PROTS-RF: a robust model for predicting mutation-induced protein stability changes.Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complexImproving computational protein design by using structure-derived sequence profile.Engineering a more thermostable blue light photo receptor Bacillus subtilis YtvA LOV domain by a computer aided rational design method.Computational design of binding proteins to EGFR domain II.On simplified global nonlinear function for fitness landscape: a case study of inverse protein folding.Optimization of van der Waals energy for protein side-chain placement and design.Protein side chain conformation predictions with an MMGBSA energy function.Application of Rigidity Theory to the Thermostabilization of Lipase A from Bacillus subtilisIdentification of functional paralog shift mutations: conversion of Escherichia coli malate dehydrogenase to a lactate dehydrogenase.Assessing predictors of changes in protein stability upon mutation using self-consistencyRosetta:MSF: a modular framework for multi-state computational protein design.Is it possible to stabilize a thermophilic protein further using sequences and structures of mesophilic proteins: a theoretical case study concerning DgAS.
P2860
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P2860
Energy functions for protein design: adjustment with protein-protein complex affinities, models for the unfolded state, and negative design of solubility and specificity.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Energy functions for protein d ...... of solubility and specificity.
@ast
Energy functions for protein d ...... of solubility and specificity.
@en
type
label
Energy functions for protein d ...... of solubility and specificity.
@ast
Energy functions for protein d ...... of solubility and specificity.
@en
prefLabel
Energy functions for protein d ...... of solubility and specificity.
@ast
Energy functions for protein d ...... of solubility and specificity.
@en
P1476
Energy functions for protein d ...... of solubility and specificity.
@en
P2093
Tracy M Handel
P304
P356
10.1016/J.JMB.2004.12.019
P407
P50
P577
2005-01-20T00:00:00Z