Predicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design.
about
Causes of evolutionary rate variation among protein sitesFunctional Sites Induce Long-Range Evolutionary Constraints in EnzymesThe utility of protein structure as a predictor of site-wise dN/dS varies widely among HIV-1 proteins.Time dependence of evolutionary metrics during the 2009 pandemic influenza virus outbreak.Dissecting the roles of local packing density and longer-range effects in protein sequence evolutionComputational prediction of the tolerance to amino-acid deletion in green-fluorescent protein.Too packed to change: side-chain packing and site-specific substitution rates in protein evolutionGeometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 HemagglutininFunctional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and FunctionalityIdentification of Novel N-Glycosylation Sites at Noncanonical Protein Consensus Motifs.Identification of positive selection in genes is greatly improved by using experimentally informed site-specific models.Calculating site-specific evolutionary rates at the amino-acid or codon level yields similar rate estimates.Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites.Intermediate divergence levels maximize the strength of structure-sequence correlations in enzymes and viral proteins.Measuring evolutionary rates of proteins in a structural context.Experimental determination and prediction of the fitness effects of random point mutations in the biosynthetic enzyme HisA.Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory.
P2860
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P2860
Predicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design.
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Predicting evolutionary site v ...... king, flexibility, and design.
@ast
Predicting evolutionary site v ...... king, flexibility, and design.
@en
type
label
Predicting evolutionary site v ...... king, flexibility, and design.
@ast
Predicting evolutionary site v ...... king, flexibility, and design.
@en
prefLabel
Predicting evolutionary site v ...... king, flexibility, and design.
@ast
Predicting evolutionary site v ...... king, flexibility, and design.
@en
P2093
P2860
P50
P1476
Predicting evolutionary site v ...... king, flexibility, and design.
@en
P2093
Amir Shahmoradi
Eleisha L Jackson
Eric T Dawson
Stephanie J Spielman
P2860
P2888
P304
P356
10.1007/S00239-014-9644-X
P577
2014-09-13T00:00:00Z
P5875
P6179
1047586858