Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.
about
Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint ApproachModeling enzyme-ligand binding in drug discoveryStructure-based function prediction of uncharacterized protein using binding sites comparisonConservation of Protein Structure over Four Billion YearsGeomfinder: a multi-feature identifier of similar three-dimensional protein patterns: a ligand-independent approachRaloxifene attenuates Pseudomonas aeruginosa pyocyanin production and virulenceProtein structure alignment beyond spatial proximityA machine learning-based method to improve docking scoring functions and its application to drug repurposingA multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homologyBinding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurementsDrug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitorsDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisDrug off-target effects predicted using structural analysis in the context of a metabolic network modelFLORA: a novel method to predict protein function from structure in diverse superfamiliesThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsDrug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavirUsing multiple microenvironments to find similar ligand-binding sites: application to kinase inhibitor bindingDrug Promiscuity in PDB: Protein Binding Site Similarity Is KeyA comprehensive survey of small-molecule binding pockets in proteinsTowards structural systems pharmacology to study complex diseases and personalized medicineeMatchSite: sequence order-independent structure alignments of ligand binding pockets in protein modelsProteochemometric modeling of the antigen-antibody interaction: new fingerprints for antigen, antibody and epitope-paratope interactionAn Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based CofactorsLarge-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug RepurposingStructure-guided selection of specificity determining positions in the human KinomeAn aggregate analysis of many predicted structures to reduce errors in protein structure comparison caused by conformational flexibilityVASP-E: specificity annotation with a volumetric analysis of electrostatic isopotentials.How a spatial arrangement of secondary structure elements is dispersed in the universe of protein folds.On the role of physics and evolution in dictating protein structure and functionExploring the structure and function paradigm.BioGPS: navigating biological space to predict polypharmacology, off-targeting, and selectivity.Cross-over between discrete and continuous protein structure space: insights into automatic classification and networks of protein structures.Nothing about protein structure classification makes sense except in the light of evolution.Discrete-continuous duality of protein structure space.Structural relationships among proteins with different global topologies and their implications for function annotation strategiesAnalysis of substructural variation in families of enzymatic proteins with applications to protein function prediction.SMAP-WS: a parallel web service for structural proteome-wide ligand-binding site comparison.GIRAF: a method for fast search and flexible alignment of ligand binding interfaces in proteins at atomic resolution.Prototypes of elementary functional loops unravel evolutionary connections between protein functions.Characterizing the existing and potential structural space of proteins by large-scale multiple loop permutations.
P2860
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P2860
Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Detecting evolutionary relatio ...... nt profile-profile alignments.
@ast
Detecting evolutionary relatio ...... nt profile-profile alignments.
@en
type
label
Detecting evolutionary relatio ...... nt profile-profile alignments.
@ast
Detecting evolutionary relatio ...... nt profile-profile alignments.
@en
prefLabel
Detecting evolutionary relatio ...... nt profile-profile alignments.
@ast
Detecting evolutionary relatio ...... nt profile-profile alignments.
@en
P2860
P356
P1476
Detecting evolutionary relatio ...... nt profile-profile alignments.
@en
P2860
P304
P356
10.1073/PNAS.0704422105
P407
P577
2008-04-02T00:00:00Z