The Mycobacterium tuberculosis drugome and its polypharmacological implications
about
Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint ApproachStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewNew target prediction and visualization tools incorporating open source molecular fingerprints for TB Mobile 2.0Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leadsA machine learning-based method to improve docking scoring functions and its application to drug repurposingProteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosisDrug Promiscuity in PDB: Protein Binding Site Similarity Is KeyTowards structural systems pharmacology to study complex diseases and personalized medicinePros and cons of the tuberculosis drugome approach--an empirical analysisCombining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug DiscoveryImproved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem.Reproducibility of computational workflows is automated using continuous analysisHarnessing Big Data for Systems PharmacologyTiPs: a database of therapeutic targets in pathogens and associated toolsTuberQ: a Mycobacterium tuberculosis protein druggability databaseBioinformatics and Drug Discovery.An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92.Comparative genomics of cell envelope components in mycobacteria.Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association.Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target IdentificationSanjeevini: a freely accessible web-server for target directed lead molecule discoveryStructure-based systems biology for analyzing off-target bindingAntibacterial mechanisms identified through structural systems pharmacology.Quantifying reproducibility in computational biology: the case of the tuberculosis drugomeDrug-target network in myocardial infarction reveals multiple side effects of unrelated drugs.An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targetsDrug repurposing to target Ebola virus replication and virulence using structural systems pharmacology.In silico approaches and chemical space of anti-P-type ATPase compounds for discovering new antituberculous drugs.Drug repurposing: far beyond new targets for old drugs.Large-scale data-driven integrative framework for extracting essential targets and processes from disease-associated gene data sets.Resistome analysis of Mycobacterium tuberculosis: Identification of aminoglycoside 2'-Nacetyltransferase (AAC) as co-target for drug desigining.Genetic-and-Epigenetic Interspecies Networks for Cross-Talk Mechanisms in Human Macrophages and Dendritic Cells during MTB Infection.Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection.Use of secondary structure element information in drug design: polypharmacology and conserved motifs in protein-ligand binding and protein-protein interfaces.The progress made in determining the Mycobacterium tuberculosis structural proteomeThe future for early-stage tuberculosis drug discoveryUtility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs.Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case.
P2860
Q24672143-9AA452F5-ECC3-48A6-87B8-460BF745FB34Q27008867-A89311BE-11E3-4E0D-BAC5-7743E6B77408Q27902272-509904F4-EB33-41D7-9F35-CC6808D66C1EQ27972942-B721E647-F171-42A8-97DC-33BFA2B4A376Q28304560-4ABC0C48-3F30-4657-AAE2-ACAB7DDF21B8Q28479221-F1FBD894-40AB-4D31-A4D2-BCB319243C80Q28534178-50D06136-DBCB-47E8-AB84-C28CDD0459A4Q28538838-C05CD9BE-7070-4F83-8711-4BD429F72C7CQ28540138-556697B4-2C4F-4B5A-8414-9E303CF3497CQ28550561-11AAF714-B152-4714-B5EE-F0BECAFECAFDQ28817549-0785FF76-F343-49BB-94EA-71E3B4622A39Q28950439-A76A6E7E-A37C-425A-80AA-20CA2BBCE4FDQ28969528-88E0FD1B-61AC-4938-AAF8-E68B1EC5EFE5Q29048180-38D6466E-4055-4325-A7C0-BA3795A307D2Q30362399-3E548D48-34BD-4E0B-8BF5-1E9D9D9E76B5Q30395256-D369B673-2AB6-42D8-8167-CFBCA3C6A590Q31034683-36722ED0-DC64-426B-94B9-5446514A82BDQ33900542-2EF7823B-F3C6-4F20-A542-2B9B3E23BFA5Q33917845-1994D328-C537-41BD-A8CB-0449920A702FQ34108424-262B86F5-C683-4065-B44E-871E5F27350AQ34530633-B78CED23-5A9F-489E-BDBF-53416C3E0F84Q34761978-325E3F7C-12C6-457E-9283-76F71E95D71AQ35013607-879F2218-E382-4E19-A8EF-DDBEB23BAD23Q35060267-3ECDF141-01E5-44CB-9EE0-E939D31F2CB2Q35551379-CB9C4270-9594-40C2-8DD5-8FBE2F732D71Q35652200-11C314FC-B707-42DA-B3F6-A262CB2A257FQ35926542-04E87E52-B5A6-46C1-B171-74186F012D20Q36256916-15FE4C38-B2AE-4012-B077-83692FB92F39Q36331528-DA9D9567-D581-4D36-BB15-F08899B5D937Q36375717-ABFE2DEF-4C24-49BC-B5D3-01DFF1AF3DFCQ36700497-907802A0-9DC6-436D-8BB8-2DE3DE53F3D8Q37345281-3E5050F7-9032-44A3-A720-E20027638EB7Q37733252-0FFBBA21-DA51-4DE7-8259-17DA80456C58Q37873477-7DD33A0D-B488-423F-81D5-4AC050F09931Q37889857-ACF86182-4CD7-4CDE-BFE5-C2A819B567A1Q38358621-A3FDBD15-6249-4991-BCF0-5F59E9361B15Q38792855-5C2C3C6F-1949-47EF-AF41-A7BE5ABD4164Q38827332-E53D0828-4F8A-4574-86E0-81CE2CC09971Q39019116-9EEEC58B-D89A-4367-B528-4BA7A1BBA0D4Q39609944-3BD0C35F-79BB-4FA2-924D-C79FCDAE958F
P2860
The Mycobacterium tuberculosis drugome and its polypharmacological implications
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@ast
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@en
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@nl
type
label
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@ast
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@en
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@nl
prefLabel
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@ast
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@en
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@nl
P2093
P2860
P50
P3181
P1476
The Mycobacterium tuberculosis drugome and its polypharmacological implications
@en
P2093
Kingston H Fung
Richard M Jackson
Sarah L Kinnings
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1000976
P407
P577
2010-11-04T00:00:00Z