about
Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flavivirusesPCDB: a database of protein conformational diversityThree-dimensional structures of membrane proteins from genomic sequencingExploring protein fitness landscapes by directed evolutionConsensus protein designMechanisms of amyloid formation revealed by solution NMRGene duplication and the evolution of moonlighting proteinsPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Mechanisms of functional promiscuity by HP1 proteinsShedding light on protein folding, structural and functional dynamics by single molecule studiesThe role of robustness in phenotypic adaptation and innovationCurrent overview of allergens of plant pathogenesis related protein familiesDesign principles underpinning the regulatory diversity of protein kinasesUnmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovationFollowing evolutionary paths to protein-protein interactions with high affinity and selectivityStructural Basis for Evolution of Product Diversity in Soybean Glutathione BiosynthesisHidden alternative structures of proline isomerase essential for catalysisA Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination ActivitiesIdentification and analysis of residues contained on β → α loops of the dual-substrate (βα)8phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activityMetamorphic proteins mediate evolutionary transitions of structureSolution structure and conformational heterogeneity of acylphosphatase from Bacillus subtilisThe two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressureTowards a restriction proteinase: construction of a self-activating enzymeBisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosisAn α Helix to β Barrel Domain Switch Transforms the Transcription Factor RfaH into a Translation FactorPeripheral insertion modulates the editing activity of the isolated CP1 domain of leucyl-tRNA synthetaseSolution structure of a minor and transiently formed state of a T4 lysozyme mutantConversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closingStructure and dynamics of a primordial catalytic fold generated by in vitro evolutionIron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobeStructural Instability Tuning as a Regulatory Mechanism in Protein-Protein InteractionsA Single Mutation in a Regulatory Protein Produces Evolvable Allosterically Regulated Catalyst of Nonnatural ReactionEvolution of a designed retro-aldolase leads to complete active site remodelingConservation of Protein Structure over Four Billion YearsDifferential active site loop conformations mediate promiscuous activities in the lactonase SsoPoxBridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiencyA designed supramolecular protein assembly with in vivo enzymatic activityDirected divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substratesA Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Protein dynamism and evolvability.
@ast
Protein dynamism and evolvability.
@en
type
label
Protein dynamism and evolvability.
@ast
Protein dynamism and evolvability.
@en
prefLabel
Protein dynamism and evolvability.
@ast
Protein dynamism and evolvability.
@en
P2860
P356
P1433
P1476
Protein dynamism and evolvability.
@en
P2093
Dan S Tawfik
Nobuhiko Tokuriki
P2860
P304
P356
10.1126/SCIENCE.1169375
P407
P577
2009-04-01T00:00:00Z