Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.
about
Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine DetoxificationModeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abusePhysiologic and metabolic safety of butyrylcholinesterase gene therapy in miceDesign, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.Enzyme-therapy approaches for the treatment of drug overdose and addiction.Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.His-tag truncated butyrylcholinesterase as a useful construct for in vitro characterization of wild-type and variant butyrylcholinesterases.Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-CocainePlants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in MiceUnexpected Reaction Pathway for butyrylcholinesterase-catalyzed inactivation of "hunger hormone" ghrelin.Modeling in vitro inhibition of butyrylcholinesterase using molecular docking, multi-linear regression and artificial neural network approachesA highly efficient cocaine-detoxifying enzyme obtained by computational design.Reaction Pathway for Cocaine Hydrolase-Catalyzed Hydrolysis of (+)-Cocaine.Reaction pathways and free energy profiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine.Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations.Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivityCatalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine.Substrate selectivity of high-activity mutants of human butyrylcholinesterase.Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid.
P2860
Q27684298-83149D77-F83E-4420-A483-416F37A82839Q28481567-83CDA947-D7EC-413B-8A71-DEC6F18B9F25Q33831381-48CA8965-10F0-4676-B3EC-A00F3E1EDE4DQ34552012-A0601F0F-A3D9-4E90-8A87-3F0D6D20421CQ35195061-00E351F8-391F-4E09-8AAE-EFA25CD43D77Q35211968-BE360282-34A1-4ED8-AAA6-63248B0FB357Q35213459-A5513FC6-3BB0-4325-8CC3-D6795B379F30Q35243815-E928FBCD-BADE-4FC6-A2CE-D87A36ADCE54Q36311751-7B52AA4F-D694-4A3E-834D-47A1B09CB773Q36553288-EE59E718-8EF2-4AAE-B4B1-E76614118D2FQ36618739-5976E29A-4DD8-46EE-8B9C-2287D56AF599Q36628186-199FD470-5A26-4533-AD34-E65F030A637DQ37574117-C408AD00-F9CB-4645-82EF-ABB52857CB61Q37718522-DEAD11A9-567C-489D-8BFF-5B3EA728D194Q38934674-CD6CA4AA-5475-46A1-957D-011519AA1048Q39238906-AD59D8A3-4914-49DF-B26A-FEB45279E736Q39779101-8F44156C-5FDA-4FFC-B8B7-C035044FD3D0Q41620409-690AC7D4-E555-4365-A5D0-DDBE6B865A0BQ41900380-398E0259-EF69-4C7C-8531-564BB6547AAEQ41921252-B7B79133-7E76-46CB-8350-FB5193002B5CQ41992058-50416E4E-DFD7-42BC-8415-AE8E46AD5081Q42874366-3238E631-1B1D-460C-A4B6-2EA3FD7B5787Q47692181-DB546650-3A36-4CD2-8CCE-3DD4193B267D
P2860
Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Design of high-activity mutant ...... ting the catalytic efficiency.
@ast
Design of high-activity mutant ...... ting the catalytic efficiency.
@en
type
label
Design of high-activity mutant ...... ting the catalytic efficiency.
@ast
Design of high-activity mutant ...... ting the catalytic efficiency.
@en
prefLabel
Design of high-activity mutant ...... ting the catalytic efficiency.
@ast
Design of high-activity mutant ...... ting the catalytic efficiency.
@en
P2093
P2860
P356
P1433
P1476
Design of high-activity mutant ...... ting the catalytic efficiency.
@en
P2093
Chang-Guo Zhan
Fang Zheng
Junjun Liu
Shurong Hou
Wenchao Yang
P2860
P304
P356
10.1021/BI1011628
P407
P577
2010-10-01T00:00:00Z