A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. - Wikidata - awgldk - TriplyDB

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.

http://www.wikidata.org/entity/Q30493126

about

Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design Most efficient cocaine hydrolase designed by virtual screening of transition states Long-acting cocaine hydrolase for addiction therapy A Thermally Stable Form of Bacterial Cocaine Esterase: A Potential Therapeutic Agent for Treatment of Cocaine Abuse Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine Biologic Approaches to Treat Substance-Use Disorders Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse Gene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicity Design of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice Anti-relapse medications: preclinical models for drug addiction treatment.Anti-cocaine vaccine development.The future potential for cocaine vaccines.Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity Novel pharmacological approaches to treatment of drug overdose and addiction Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase.Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes.Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine.Enzyme-therapy approaches for the treatment of drug overdose and addiction.Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene.Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine.Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose?Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects.Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction Pharmacokinetic strategies for treatment of drug overdose and addiction.Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months.Modification of pharmacokinetic and abuse-related effects of cocaine by human-derived cocaine hydrolase in monkeys Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.A controlled trial of the adjunct use of D-cycloserine to facilitate cognitive behavioral therapy outcomes in a cocaine-dependent population Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse.Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity.

P2860

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P2860

A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.

http://www.wikidata.org/entity/Q30493126

description

2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

A cocaine hydrolase engineered ...... ement of drug seeking in rats.

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A cocaine hydrolase engineered ...... ement of drug seeking in rats.

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type

label

A cocaine hydrolase engineered ...... ement of drug seeking in rats.

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A cocaine hydrolase engineered ...... ement of drug seeking in rats.

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A cocaine hydrolase engineered ...... ement of drug seeking in rats.

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A cocaine hydrolase engineered ...... ement of drug seeking in rats.

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Neuropsychopharmacology

P1476

A cocaine hydrolase engineered ...... tement of drug seeking in rats

@en

P2093

David Lafleur

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Luke A Gliddon

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M Singh

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Marilyn E Carroll

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Qinghai Zhao

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R Shah

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Stephen Brimijoin

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Yang Gao

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P2860

Crystal structure of a bacterial cocaine esterase

Biochemical characterization and structural analysis of a highly proficient cocaine esterase

Estimation and disposition of [3H]benzoylecgonine and pharmacological activity of some cocaine metabolites

Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1

A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats

The neural basis of addiction: a pathology of motivation and choice

The reinstatement model of drug relapse: history, methodology and major findings

Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins.

Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.

Identification and characterization of single chain anti-cocaine catalytic antibodies

P2888

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2715-2725

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scholarly article

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10.1038/SJ.NPP.1301666

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11

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33

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2008-01-16T00:00:00Z

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1012940150

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18199998

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2562914

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