In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir.
about
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activityI222 Neuraminidase mutations further reduce oseltamivir susceptibility of Indonesian Clade 2.1 highly pathogenic Avian Influenza A(H5N1) virusesPandemic 2009 H1N1 influenza A virus carrying a Q136K mutation in the neuraminidase gene is resistant to zanamivir but exhibits reduced fitness in the guinea pig transmission model.Evaluation of recombinant 2009 pandemic influenza A (H1N1) viruses harboring zanamivir resistance mutations in mice and ferrets.A cutting-edge view on the current state of antiviral drug development.Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.Understanding the cross-resistance of oseltamivir to H1N1 and H5N1 influenza A neuraminidase mutations using multidimensional computational analyses.Reduced susceptibility to all neuraminidase inhibitors of influenza H1N1 viruses with haemagglutinin mutations and mutations in non-conserved residues of the neuraminidase.Detection and management of antiviral resistance for influenza viruses.Solid phase assay for comparing reactivation rates of neuraminidases of influenza wild type and resistant mutants after inhibitor removal.
P2860
Q27684054-C8D268A9-6D92-4369-9734-E043314B50C8Q28533778-1AB88C46-E410-476E-B30A-07683AF17F42Q30424185-5AD3929D-A7E5-4B43-B4CC-40080AF6E04AQ30426441-E7BABD27-5D3E-4EA5-A7AF-3999C476A625Q34036018-98C3831F-69AE-4019-89E3-E2052B41C562Q35056208-1F0DE149-4DB1-4705-85F9-B9662AE73AD4Q35923779-59F797AB-FA32-48DF-A2E5-71EDBB3DFDB5Q37169942-76DC6DC4-0E56-470B-829C-7001AEF43DFCQ38161553-29319526-1ED2-44D5-9BC1-1D717B3E7376Q42116998-3794E48D-72CC-4694-8FDF-4ED3719F0BE6
P2860
In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@ast
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@en
type
label
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@ast
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@en
prefLabel
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@ast
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@en
P2093
P2860
P356
P1476
In vitro passaging of a pandem ...... ramivir, but not to zanamivir.
@en
P2093
Christina Rootes
Peter G Mohr
Victor A Streltsov
P2860
P304
P356
10.1093/JAC/DKS150
P407
P577
2012-05-04T00:00:00Z