Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure.
about
Predicting deleterious amino acid substitutionsSimple evolutionary pathways to complex proteinsSimulating evolution by gene duplication of protein features that require multiple amino acid residuesAllostery in the LacI/GalR family: variations on a themePrediction of solvent accessibility and sites of deleterious mutations from protein sequence.Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicityA protein functional leap: how a single mutation reverses the function of the transcription regulator TetRRheostats and toggle switches for modulating protein functionFast reconstruction of compact context-specific metabolic network modelsUse of mutation spectra analysis software.Persistently conserved positions in structurally similar, sequence dissimilar proteins: roles in preserving protein fold and function.Mutagenesis-based definitions and probes of residue burial in proteins.Amino acid positions subject to multiple coevolutionary constraints can be robustly identified by their eigenvector network centrality scoresAlloRep: A Repository of Sequence, Structural and Mutagenesis Data for the LacI/GalR Transcription RegulatorsData on publications, structural analyses, and queries used to build and utilize the AlloRep database.Predicting the effect of missense mutations on protein function: analysis with Bayesian networks.Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategyIdentification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity.Bi-directional SIFT predicts a subset of activating mutations.Transposon assisted gene insertion technology (TAGIT): a tool for generating fluorescent fusion proteins.ProPhylER: a curated online resource for protein function and structure based on evolutionary constraint analyses.The use of orthologous sequences to predict the impact of amino acid substitutions on protein function.Comparing the functional roles of nonconserved sequence positions in homologous transcription repressors: implications for sequence/function analyses.An automated stochastic approach to the identification of the protein specificity determinants and functional subfamilies.Functional classification of proteins and protein variants.Mutations in transcriptional regulators allow selective engineering of signal integration logic.Visualizing high error levels during gene expression in living bacterial cells.Determinants, discriminants, conserved residues--a heuristic approach to detection of functional divergence in protein familiesGenetic flexibility of regulatory networksNeighborhood properties are important determinants of temperature sensitive mutations.Economical evolution: microbes reduce the synthetic cost of extracellular proteins.Functionally important positions can comprise the majority of a protein's architecture.The stress of protein misfolding: from single cells to multicellular organismsComparison of deterministic and stochastic models of the lac operon genetic network.Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution.Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthaseSingle nucleotide variations: biological impact and theoretical interpretation.A cellular perspective on conformational disease: the role of genetic background and proteostasis networks.Genetic constraints on protein evolution
P2860
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P2860
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure.
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Genetic studies of the Lac rep ...... asis of the protein structure.
@ast
Genetic studies of the Lac rep ...... asis of the protein structure.
@en
type
label
Genetic studies of the Lac rep ...... asis of the protein structure.
@ast
Genetic studies of the Lac rep ...... asis of the protein structure.
@en
prefLabel
Genetic studies of the Lac rep ...... asis of the protein structure.
@ast
Genetic studies of the Lac rep ...... asis of the protein structure.
@en
P2093
P356
P1476
Genetic studies of the Lac rep ...... asis of the protein structure.
@en
P2093
Kisters-Woike B
Markiewicz P
Müller-Hill B
P304
P356
10.1006/JMBI.1996.0479
P407
P577
1996-08-01T00:00:00Z