The stress of protein misfolding: from single cells to multicellular organisms
about
Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complexHistone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiencyHeat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseasesMetazoan Hsp70-based protein disaggregases: emergence and mechanismsExpanding proteostasis by membrane trafficking networksSorting out the trash: the spatial nature of eukaryotic protein quality controlRegulation of cellular protein quality control networks in a multicellular organismChaperone machines for protein folding, unfolding and disaggregationAn intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregationModulation of the maladaptive stress response to manage diseases of protein foldingNeuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock responseCytoplasmic mRNA turnover and ageingProteomics of protein post-translational modifications implicated in neurodegenerationCharacterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegansAggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assaysMalfolded protein structure and proteostasis in lung diseases.Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset.The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Proteostasis and the aging proteome in health and disease.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesUsing pharmacological chaperones to restore proteostasisUsing Caenorhabditis elegans as a model system to study protein homeostasis in a multicellular organism.Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteomeMolecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins.The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free systemA chaperone trap contributes to the onset of cystic fibrosis.Bis is Induced by Oxidative Stress via Activation of HSF1Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptorsNatural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans.Sirt1-deficiency causes defective protein quality controlProteostasis and REDOX state in the heart.Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegansDirect link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α.Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling.Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish modelThinking laterally about neurodegenerative proteinopathies.Understanding protein aggregation from the view of monomer dynamics
P2860
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P2860
The stress of protein misfolding: from single cells to multicellular organisms
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The stress of protein misfolding: from single cells to multicellular organisms
@ast
The stress of protein misfolding: from single cells to multicellular organisms
@en
The stress of protein misfolding: from single cells to multicellular organisms
@nl
type
label
The stress of protein misfolding: from single cells to multicellular organisms
@ast
The stress of protein misfolding: from single cells to multicellular organisms
@en
The stress of protein misfolding: from single cells to multicellular organisms
@nl
prefLabel
The stress of protein misfolding: from single cells to multicellular organisms
@ast
The stress of protein misfolding: from single cells to multicellular organisms
@en
The stress of protein misfolding: from single cells to multicellular organisms
@nl
P2860
P1476
The stress of protein misfolding: from single cells to multicellular organisms
@en
P2093
Richard I Morimoto
Veena Prahlad
P2860
P356
10.1101/CSHPERSPECT.A009704
P577
2011-06-01T00:00:00Z