Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
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Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingLipins, lipinopathies, and the modulation of cellular lipid storage and signalingMultifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscleDiacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytesThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingA neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeastThe Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate AcyltransferaseInhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes.Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulationCritical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in micePhylogenetic analysis of glycerol 3-phosphate acyltransferases in opisthokonts reveals unexpected ancestral complexity and novel modern biosynthetic components.S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding.Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D.Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiationMouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.A TORC2-Akt Feed-Forward Topology Underlies HER3 Resiliency in HER2-Amplified Cancers.Distinct roles for alpha-beta hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling.Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese miceHepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation.Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis.Phosphatidic acid and lipid-sensing by mTORNutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα.Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidationHepatic fatty acid trafficking: multiple forks in the roadPhospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect.Lipid signals and insulin resistance.Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice.Activation of mTOR: a culprit of Alzheimer's disease?Tracking Diacylglycerol and Phosphatidic Acid Pools in Budding Yeast.Phosphatidic acid: biosynthesis, pharmacokinetics, mechanisms of action and effect on strength and body composition in resistance-trained individuals.Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation.Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis.Phosphatidic acid: a new therapeutic lead to suppress hepatic glucose production.
P2860
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P2860
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@ast
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@en
type
label
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@ast
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@en
prefLabel
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@ast
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@en
P2093
P2860
P921
P356
P1476
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.
@en
P2093
Angela A Wendel
Chongben Zhang
Matthew R Keogh
Rosalind A Coleman
Thurl E Harris
P2860
P304
P356
10.1073/PNAS.1110730109
P407
P577
2012-01-17T00:00:00Z