Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor - Wikidata - awgldk - TriplyDB

Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor

Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor

http://www.wikidata.org/entity/Q30427155

about

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships Sequential replication-coupled destruction at G1/S ensures genome stability.Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability From START to FINISH: the influence of osmotic stress on the cell cycle USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress.Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.CRL Ubiquitin Ligases and DNA Damage Response.The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses.Flipping the switch from g1 to s phase with e3 ubiquitin ligases B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.UnCHKed DNA replication: A stressful matter.A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress.Rapid DNA replication origin licensing protects stem cell pluripotency.The Temporal Regulation of S Phase Proteins During G1.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.

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Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor

http://www.wikidata.org/entity/Q30427155

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Stress-stimulated mitogen-acti ...... A replication licensing factor

@ast

Stress-stimulated mitogen-acti ...... A replication licensing factor

@en

type

label

Stress-stimulated mitogen-acti ...... A replication licensing factor

@ast

Stress-stimulated mitogen-acti ...... A replication licensing factor

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prefLabel

Stress-stimulated mitogen-acti ...... A replication licensing factor

@ast

Stress-stimulated mitogen-acti ...... A replication licensing factor

@en

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Molecular and Cellular Biology

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Stress-stimulated mitogen-acti ...... A replication licensing factor

@en

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Jeanette Gowen Cook

http://www.w3.org/2001/XMLSchema#string

Jonathan R Hall

http://www.w3.org/2001/XMLSchema#string

Srikripa Chandrasekaran

http://www.w3.org/2001/XMLSchema#string

Ting Xu Tan

http://www.w3.org/2001/XMLSchema#string

P2860

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6

The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

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4405-4416

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scholarly article

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10.1128/MCB.06163-11

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22

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31

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2011-09-19T00:00:00Z

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51655040

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21930785

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3209262

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