Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias. - Wikidata - awgldk - TriplyDB

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

http://www.wikidata.org/entity/Q30429228

about

Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.The same pocket in menin binds both MLL and JUND but has opposite effects on transcription High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia The role of HTS in drug discovery at the University of Michigan.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes.Challenges and opportunities in targeting the menin-MLL interaction.Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?The pathogenesis of mixed-lineage leukemia.CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.Chromosomal aberrations and fusion genes in myeloid malignancies.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase.DNA methylation profiles distinguish different subtypes of gastroenteropancreatic neuroendocrine tumors.Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.Targeting human SET1/MLL family of proteins.Identifying new targets in leukemogenesis using computational approaches.Detection of disordered regions in globular proteins using ¹³C-detected NMR.PepSite: prediction of peptide-binding sites from protein surfaces.Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).Pharmacologic Inhibition of the Menin-MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules† †Electronic Supplementary Information (ESI) available: Detailed characterization of the compound c Theoretical models of inhibitory activity for inhibitors of protein-protein interactions: targeting menin-mixed lineage leukemia with small molecules.Computer-Aided Drug Design in Epigenetics.Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia.

P2860

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P2860

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

http://www.wikidata.org/entity/Q30429228

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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prefLabel

Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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JBC.M110.172783

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Journal of Biological Chemistry

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Molecular basis of the mixed l ...... eting mixed lineage leukemias.

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P2093

Amalia M Belcher

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Jolanta Grembecka

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Thomas Hartley

http://www.w3.org/2001/XMLSchema#string

Tomasz Cierpicki

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P2860

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

Global and Hox-specific roles for the MLL1 methyltransferase

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

MOLMOL: a program for display and analysis of macromolecular structures

Positional cloning of the gene for multiple endocrine neoplasia-type 1

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40690-40698

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scholarly article

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10.1074/JBC.M110.172783

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52

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285

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