Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).
about
Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifGeneration of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia TherapySpecificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.The molecular mechanics of mixed lineage leukemia.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.Regulatory variation: an emerging vantage point for cancer biology.Chromatin modifiers and the promise of epigenetic therapy in acute leukemiaEpigenetics in T-cell acute lymphoblastic leukemia.The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding.Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins.Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes.LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.
P2860
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P2860
Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Impairing MLL-fusion gene-medi ...... ved growth factor (LEDGF/p75).
@en
Impairing MLL-fusion gene-medi ...... ithelium-derived growth factor
@nl
type
label
Impairing MLL-fusion gene-medi ...... ved growth factor (LEDGF/p75).
@en
Impairing MLL-fusion gene-medi ...... ithelium-derived growth factor
@nl
prefLabel
Impairing MLL-fusion gene-medi ...... ved growth factor (LEDGF/p75).
@en
Impairing MLL-fusion gene-medi ...... ithelium-derived growth factor
@nl
P2093
P2860
P356
P1433
P1476
Impairing MLL-fusion gene-medi ...... ved growth factor (LEDGF/p75).
@en
P2093
J De Rijck
J Schwaller
K Cermáková
R Gijsbers
P2860
P2888
P304
P356
10.1038/LEU.2013.10
P577
2013-01-15T00:00:00Z
P5875
P6179
1015348647