Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
about
Androgen receptor activation in castration-recurrent prostate cancer: the role of Src-family and Ack1 tyrosine kinasesSRC: marker or actor in prostate cancer aggressivenessMolecular classification of prostate cancer progression: foundation for marker-driven treatment of prostate cancerReceptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancersDevelopment of novel ACK1/TNK2 inhibitors using a fragment-based approachACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferationAndrogen receptor phosphorylation: biological context and functional consequences.Minireview: Tipping the balance: ligand-independent activation of steroid receptors.ACK1 tyrosine kinase interacts with histone demethylase KDM3A to regulate the mammary tumor oncogene HOXA1Differential requirement for Src family tyrosine kinases in the initiation, progression, and metastasis of prostate cancerConstitutive activity of the androgen receptor.Minireview: Alternative activation pathways for the androgen receptor in prostate cancer.Androgen receptor signaling in prostate cancer development and progression.New hormonal therapies for castration-resistant prostate cancer.ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA bindingOncogene-specific activation of tyrosine kinase networks during prostate cancer progression.Outsmarting androgen receptor: creative approaches for targeting aberrant androgen signaling in advanced prostate cancerTaking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Androgen receptor: structure, role in prostate cancer and drug discovery.Large scale phosphoproteome analysis of LNCaP human prostate cancer cellsPosttranslational modification of the androgen receptor in prostate cancer.Androgen receptor regulates SRC expression through microRNA-203A novel multi-modal drug repurposing approach for identification of potent ACK1 inhibitorsSrc promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.The role of intracrine androgen metabolism, androgen receptor and apoptosis in the survival and recurrence of prostate cancer during androgen deprivation therapy.Targeting tyrosine kinases and autophagy in prostate cancer.Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer.Androgen receptor signaling in prostate cancer.Src signaling pathways in prostate cancer.Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospectsTyrosine kinase inhibitors in the treatment of prostate cancer: taking the next step in clinical development.Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer.Molecular mechanism of prostate cancer cell apoptosis induced by busulfan via adjustment of androgen receptor phosphatizationAntibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer.Randomized Phase II trial of nintedanib, afatinib and sequential combination in castration-resistant prostate cancer.Clinical appraisal of abiraterone in the treatment of metastatic prostatic cancer: patient considerations, novel opportunities, and future directions.Lyn tyrosine kinase regulates androgen receptor expression and activity in castrate-resistant prostate cancer.TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer.
P2860
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P2860
Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@ast
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@en
type
label
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@ast
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@en
prefLabel
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@ast
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@en
P2093
P2860
P356
P1433
P1476
Dasatinib inhibits site-specif ...... ceptor by Ack1 and Src kinases
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.103
P407
P50
P577
2010-04-12T00:00:00Z
P5875
P6179
1030946771