Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.
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Metabolic influences that regulate dendritic cell function in tumorsTargeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potentialComparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responsesStimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer.Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help.Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cellsCD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responsesPhase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma.CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunityDifferential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infectionGeneration of T cell responses targeting the reactive metabolite of halothane in mice.Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody-drug conjugate SGN-75Irradiation enhances human T-cell function by upregulating CD70 expression on antigen-presenting cells in vitro.CD4+ T cells play a critical role in the generation of primary and memory antitumor immune responses elicited by SA-4-1BBL and TAA-based vaccines in mouse tumor models.An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling.Th1 and Th2 cells help CD8 T-cell responses.Immunity, cancer and aging: lessons from mouse models.Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency.Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.Pancreatic ductal adenocarcinoma: a review of immunologic aspects.CD70 expression patterns in renal cell carcinoma.A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.T cell vaccinology: exploring the known unknowns.The Tower of Babel of CD8+ T-cell memory: known facts, deserted roads, muddy waters, and possible dead ends.CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells.T Cell Vaccinology: Beyond the Reflection of Infectious ResponsesThe CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactionsMultiple roles for CD4+ T cells in anti-tumor immune responses.A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory.Cancer, aging and immunotherapy: lessons learned from animal models.Enhancement of anti-tumor immunity by photodynamic therapyCostimulation signals for memory CD8+ T cells during viral infections.Plasticity in programming of effector and memory CD8 T-cell formation.ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.
P2860
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P2860
Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.
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2005 nî lūn-bûn
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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2005 թվականի հունվարին հրատարակված գիտական հոդված
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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name
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@ast
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@en
type
label
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@ast
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@en
prefLabel
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@ast
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@en
P1476
Induction of CD70 on dendritic ...... n the absence of CD4+ T cells.
@en
P2093
Hideo Yagita
Timothy N J Bullock
P304
P356
10.4049/JIMMUNOL.174.2.710
P407
P577
2005-01-01T00:00:00Z