Synthesis of a potent and selective inhibitor of p90 Rsk.
about
Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolutionRSK3: A regulator of pathological cardiac remodelingBacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2)The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.Improving the affinity of SL0101 for RSK using structure-based design.RSK2 Binding Models Delineate Key Features for ActivitySynthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangementAnchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy.Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cellsKinase inhibitors as potential agents in the treatment of multiple myeloma.Synthesis of SL0101 carbasugar analogues: carbasugars via Pd-catalyzed cyclitolization and post-cyclitolization transformationsDe novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation.De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation.Facile oxidative cleavage of 4-O-benzyl ethers with dichlorodicyanoquinone in rhamno- and mannopyranosides.The first total synthesis of apigenin 7-O-β-D-cellobiosyl-4'-O-β-D-glucopyranoside isolated from Salvia uliginosa.ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.Unveiling the 6,8-Rearrangement in 8-Phenyl-5,7-dihydroxyflavylium and 8-Methyl-5,7-dihydroxyflavylium through Host-Guest Complexation
P2860
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P2860
Synthesis of a potent and selective inhibitor of p90 Rsk.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Synthesis of a potent and selective inhibitor of p90 Rsk.
@ast
Synthesis of a potent and selective inhibitor of p90 Rsk.
@en
type
label
Synthesis of a potent and selective inhibitor of p90 Rsk.
@ast
Synthesis of a potent and selective inhibitor of p90 Rsk.
@en
prefLabel
Synthesis of a potent and selective inhibitor of p90 Rsk.
@ast
Synthesis of a potent and selective inhibitor of p90 Rsk.
@en
P356
P1433
P1476
Synthesis of a potent and selective inhibitor of p90 Rsk.
@en
P2093
David J Maloney
Sidney M Hecht
P304
P356
10.1021/OL0500463
P407
P577
2005-03-01T00:00:00Z