The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. - Wikidata - awgldk - TriplyDB

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

http://www.wikidata.org/entity/Q30441227

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Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2 The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity Mechanisms of cancer cell killing by the adenovirus E4orf4 protein Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells.PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells.Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats.Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1).NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway.Viewing serine/threonine protein phosphatases through the eyes of drug designers Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity GENE EXPRESSION PROFILING OF HUMAN LIVER CARCINOMA (HepG2) CELLS EXPOSED TO THE MARINE TOXIN OKADAIC ACID.Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins.Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration.Dynamics of protein phosphatase gene expression in Corbicula fluminea exposed to microcystin-LR and to toxic Microcystis aeruginosa cells.Deactivation of sphingosine kinase 1 by protein phosphatase 2A.Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase.Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy The role of translation initiation regulation in haematopoiesis.Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts.Methylation of protein phosphatase 2A-Influence of regulators and environmental stress factors.Protein phosphatases type 2A mediate tuberization signaling in Solanum tuberosum L. leaves.Computational study of the covalent bonding of microcystins to cysteine residues--a reaction involved in the inhibition of the PPP family of protein phosphatases.Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, alpha4 and the mammalian ortholog of yeast Tip41 (TIPRL).Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.

P2860

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P2860

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

http://www.wikidata.org/entity/Q30441227

description

2006 nî lūn-bûn

@nan

2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@ast

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@en

type

label

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@ast

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@en

prefLabel

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@ast

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@en

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

The alpha4 regulatory subunit ...... ein phosphatases PP6 and PP2A.

@en

P2093

David L Brautigan

http://www.w3.org/2001/XMLSchema#string

Todd D Prickett

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P2860

Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein

Serine/threonine protein phosphatases

Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1

Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.

TOR, a central controller of cell growth.

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2

Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)

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30503-30511

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scholarly article

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10.1074/JBC.M601054200

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P433

41

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P478

281

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2006-08-08T00:00:00Z

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P698

16895907

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