A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. - Wikidata - awgldk - TriplyDB

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.

http://www.wikidata.org/entity/Q30442429

about

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing Unexpected cellular players in Rett syndrome pathology Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus A protocol for evaluation of Rett Syndrome symptom improvement by metabolic modulators in Mecp2-mutant mice.Absence of strong strain effects in behavioral analyses of Shank3-deficient mice Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data.Data gaps limit the translational potential of preclinical research.Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic Dysfunction Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes.ENU Mutagenesis in the Mouse.Cholesterol metabolism is altered in Rett syndrome: a study on plasma and primary cultured fibroblasts derived from patients.Epigenetic regulation of cholesterol homeostasis.Cholesterol in brain disease: sometimes determinant and frequently implicated.The mouse MC13 mutant is a novel ENU mutation in collagen type II, alpha 1 MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.PTP1B inhibition suggests a therapeutic strategy for Rett syndrome PTP1B: a new therapeutic target for Rett syndrome Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome.Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice.Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes Effects of ω-3 polyunsaturated fatty acids on plasma proteome in Rett syndrome.Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome.Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex.Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome Methyl-CpG-Binding Protein MBD1 Regulates Neuronal Lineage Commitment through Maintaining Adult Neural Stem Cell Identity Alterations in the carnitine cycle in a mouse model of Rett syndrome.Lipid rafts: a signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders.A role for metabolism in Rett syndrome pathogenesis: New clinical findings and potential treatment targets.Rett syndrome: a complex disorder with simple roots.Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.Genetic Approaches to Understanding Psychiatric Disease.Mechanisms of suppression: The wiring of genetic resilience.Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway During Neuronal Differentiation In Vitro.Simvastatin inhibits protein isoprenylation in the brain.Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder.

P2860

Q21131923-E4F18E76-3067-4F38-AA57-83AE99E158B9 Q26785773-196869C2-32D3-4F0B-8090-F7758436821E Q30299929-23CA98F6-2A7B-46CC-AD42-57F27192096B Q30355025-B84DF620-6502-46C4-A548-3B0B16E3A884 Q30422702-9B1773AC-63D8-4647-93B6-B87CDE859C19 Q30435402-A990519D-8088-4E94-9D22-271A66C29CD3 Q30721849-1164B7C8-0BBE-47F8-A5AE-C1A662924F44 Q31035567-1C7D32FF-75D3-461C-AD4F-6BCC48ECA6E2 Q33607803-BE13C10D-8CEC-486A-B85D-5A0F7ECDC0FE Q33826769-2F2454D7-C448-43D6-AC2B-820EDD23629A Q33836894-B6274219-4A17-4177-99CA-E2B9D39B869F Q33964080-71E90B94-35AA-4B3F-82F8-A74070BD301A Q34035419-BBCC06E4-234F-45FE-BF9B-726D78BF1D72 Q34238886-9475DFA5-EA60-4FD0-8EE5-6AD00389766B Q34621446-C7A9FF50-A3C3-4579-9E3C-A6E5C2F6A3A7 Q34777036-A2C336F3-566D-4CBA-9711-F4FFF1DE7645 Q35995005-BA28F4A7-C69D-4D50-9BAA-736C166D5438 Q36040491-DD6F745C-578E-4729-A564-9C16E91BB82B Q36040548-0733D778-FF7A-499D-A01E-62ED47965522 Q36187325-52B7CA4D-52A1-48C2-84D5-B2F2ECAA8EB6 Q36540413-7323BB35-C8A0-4F07-90A8-C8A627F1882F Q36772356-3998807C-A601-4BCE-A6D9-340271299513 Q37412677-FF0AED35-4214-4F6E-8F0C-00C0F0879050 Q37424386-0D85EA4A-F312-4015-96A8-1445685898CA Q37462636-F50824D9-2277-4F8B-BB91-F2AB3EEE17F3 Q37530115-4E7B931B-A55A-4391-A9C4-D6DF16673DBA Q37530120-075477EE-28DC-4532-931B-61D6FFE0FD74 Q37553799-D5CB581E-130B-4976-8D7D-F169A41BF00B Q37592163-31813F04-43A8-4CA6-BBAC-04D83B0B756E Q37620699-A8F7212A-058F-46F1-88AA-3B75A56FA6C4 Q37681389-D0E3B0CA-EB75-48A7-AAED-C2174B8CEDEE Q37690669-2327B19A-A20D-4129-A1A5-AE1ED20D8CF9 Q38366899-4DDCD11B-7E76-4039-8C06-BED1E41FD81F Q38615493-344D9D69-8E33-4744-8511-6F4A250273CC Q38728415-EBC76361-A94A-4239-ACBF-566999559291 Q38743147-A912F7B9-2FE5-47E1-B8DE-3032C38EF9D1 Q38759135-AD591348-60CA-4701-9223-E86955C956CE Q38770832-27D40EF1-4685-4D89-A292-3B31CDDDB50E Q38896297-59EAE0DC-A9C1-4644-9941-33D41071C0E9 Q39003033-4AFFB788-9669-4241-B162-D0DC48A38766

P2860

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.

http://www.wikidata.org/entity/Q30442429

description

2013 nî lūn-bûn

@nan

2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@ast

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@en

type

label

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@ast

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@en

prefLabel

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@ast

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@en

P1433

Q30442429-71E95A27-4442-4E72-88D6-AACF78B8469B

P1476

Q30442429-89820655-EE14-4DD6-BE00-2406EF75E86D

P2093

Q30442429-00280751-9637-418A-A9E7-49D6C6127894

Q30442429-3AB0F4D8-A959-4D1E-934B-3496F9849789

Q30442429-42BEDBB2-9274-434B-A078-8513B497A1D5

Q30442429-613CC7FC-AE0A-46A2-B048-ABBA121621FA

Q30442429-9FC14AD4-B5C1-444D-974E-12B83BC7243E

Q30442429-B8E026FE-D9E6-4536-82F2-5B962AECDD72

Q30442429-BE0C22C2-2F97-44BD-9BBD-22E1D8906BB2

Q30442429-C8F266DE-613D-4199-82B0-B48A1793E00A

Q30442429-D94E7B61-9A7A-4795-878A-515669A446D6

Q30442429-EC48859D-B0F6-48E6-BEA5-25CA497CE41B

P2860

Q30442429-0318362D-235A-41D3-AD4A-2F96C6C57F65

Q30442429-0E1526DE-7527-4CAD-BE10-DDB71B8F7D8C

Q30442429-0E8480DE-B58D-4367-8D05-986AC4EEBE25

Q30442429-0EF0CA95-0D26-4259-91EF-3ABF9FD78E17

Q30442429-142D2643-6303-4C93-96C4-5ACC9D2EE4C8

Q30442429-256A3F2F-2C9D-4BC3-8EDB-EDECD541EE91

Q30442429-27EE11C7-1134-4ABE-B094-0777C67D5938

Q30442429-2B5D69C2-873F-429B-B0B2-A41B53D0CDFE

Q30442429-2F29F8B4-DAF6-4703-A787-5503B538375B

Q30442429-31619DFF-9814-45D9-9105-91980A2B56CA

P2888

Q30442429-E9C5E590-9C0B-49A4-93FC-F94D41AA66D6

P304

Q30442429-5A7629E4-310F-4D38-A4F9-20A26DA4F8AD

P31

Q30442429-6BE32851-04F9-4EA9-8304-184A2A24A798

P356

Q30442429-3AF411DE-4450-4436-80CC-81D3054C250E

P407

Q30442429-7754D698-E617-42BE-8434-5FDAF522AA67

P433

Q30442429-552718FD-BF57-4A50-9F5C-A8AC66C4EDDA

P478

Q30442429-5714248A-1FAF-4FCA-B32E-0C89E45CDF8F

P50

Q30442429-9DE14309-5B2D-4F3F-9456-75DB64905474

Q30442429-D975CA48-7100-4608-9D6B-ADC233F158B3

P577

Q30442429-58F9CBE5-E36D-4286-98BB-3E944BB92685

P5875

Q30442429-310A8D75-B5A0-46FC-BF58-37BC725CE878

P698

Q30442429-BF00408D-34BD-4248-A4B9-43A17CFB4ADD

P932

Q30442429-30447A50-158E-475B-92FF-CB8616B18159

P356

P1433

Nature Genetics

P1476

A suppressor screen in Mecp2 m ...... l metabolism in Rett syndrome.

@en

P2093

Andrew A Pieper

http://www.w3.org/2001/XMLSchema#string

Benny Liu

http://www.w3.org/2001/XMLSchema#string

Christie M Buchovecky

http://www.w3.org/2001/XMLSchema#string

David M Katz

http://www.w3.org/2001/XMLSchema#string

Hannah M Brown

http://www.w3.org/2001/XMLSchema#string

Jeffrey G McDonald

http://www.w3.org/2001/XMLSchema#string

Monica J Justice

http://www.w3.org/2001/XMLSchema#string

Stephanie M Kyle

http://www.w3.org/2001/XMLSchema#string

Stephen D Turley

http://www.w3.org/2001/XMLSchema#string

Wenhui Huang

http://www.w3.org/2001/XMLSchema#string

P2860

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis

Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain

MeCP2, a key contributor to neurological disease, activates and represses transcription

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

The Sequence Alignment/Map format and SAMtools

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

Functional genetic analysis of mouse chromosome 11

Mechanisms and functions of Hedgehog signalling across the metazoa

P2888

P304

1013-1020

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NG.2714

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

45

http://www.w3.org/2001/XMLSchema#string

P50

David W. Russell

P577

2013-07-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

253334942

http://www.w3.org/2001/XMLSchema#string

P698

23892605

http://www.w3.org/2001/XMLSchema#string

P932

3837522

http://www.w3.org/2001/XMLSchema#string