The timing of TCR alpha expression critically influences T cell development and selection
about
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activationNKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biologyCentral tolerance: learning self-control in the thymusThe role of the gut as a primary lymphoid organ: CD8αα intraepithelial T lymphocytes in euthymic mice derive from very immature CD44+ thymocyte precursorsBCL11B is required for positive selection and survival of double-positive thymocytesDistinct temporal patterns of T cell receptor signaling during positive versus negative selection in situLineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.The presence of CD8+ invariant NKT cells in mice.Mechanisms of self-nonself discrimination and possible clinical relevance.TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexesThe role of the thymus in tolerance.T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunityElevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage.Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy.Self-specific CD8+ T cells maintain a semi-naive state following lymphopenia-induced proliferation.Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD miceReceptor editing in lymphocyte development and central tolerance.The impact of circulating dendritic cells on the development and differentiation of thymocytes.A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.Targeted Sos1 deletion reveals its critical role in early T-cell development.Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.Differential regulation of proximal and distal Vbeta segments upstream of a functional VDJbeta1 rearrangement upon beta-selectionStage-dependent reactivity of thymocytes to self-peptide--MHC complexes.Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cellsClonal deletion and the fate of autoreactive thymocytes that survive negative selection.Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyteThe E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cellsMechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition.Selection of Thymocytes Expressing Transgenic TCR Specific for a Minor Histocompatibility Antigen, H60.Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.The role of apoptosis in the development and function of T lymphocytes.Examination of thymic positive and negative selection by flow cytometry.Central tolerance: good but imperfect.A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signalingTargeting thymic epithelia AR enhances T-cell reconstitution and bone marrow transplant grafting efficacy.A long journey coming to fruition: In sight of the preselection T-cell repertoireRequirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks.Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine.
P2860
Q24293190-DC83C688-276D-4F26-B75B-019BECA1EBDAQ27317219-D23DF96F-BF3D-4B6E-9504-C5838E6324D3Q28275215-BCFF7CD7-1866-49A5-BFA2-72A364026A84Q28291483-E0F3F52B-D44F-4494-8828-5BADA986FF45Q28590236-A6C369C6-3817-48C8-8929-46C634C92737Q30582285-5A2B7453-7A98-4410-915D-7F9C4BC33595Q33317281-41FC9AC6-A4F6-4310-92B8-01E21639961EQ33523813-703A104E-3B55-498C-85FA-725548CF2B16Q33575769-8468C739-AE3C-4701-8ACC-A0353DAE305CQ33617746-BC05A192-90B1-4F04-B452-02B5ABD04EA5Q33865169-9949A24A-1784-414D-A3EA-093574FA27A1Q34103905-3F064C79-366A-4C16-9A45-A3A61F6456C8Q34228163-C76C4A22-4285-41E7-A3BA-2BBADC3F4133Q34301124-95BA9DEA-39B7-4136-9A90-7CAC7B5326EFQ34363238-CA5232C9-6F21-472B-86D6-686D62AFDFB3Q34470833-D81928FD-3488-40BF-A80D-A4A1A814FF11Q34527126-46EA9410-FB46-4835-9648-1532950E60B2Q34568574-E6957486-F0CC-4EE9-8045-2E80D15DA63FQ34601204-07D2F956-9635-432C-8F64-31EEDAE4E4FEQ35105448-4A42CD58-7DD8-4E4C-963B-ED9BD0031EAAQ35134263-EFC982CB-6DAD-46D8-8533-255240FF6B46Q35197906-2131B63E-C7A7-4EF9-8804-86E4197130D1Q35204599-386008E2-4D30-49C4-8CCA-A077238890EDQ35691052-5EF9B4D2-730C-4891-9652-43A1A97B8A00Q35815577-450D5134-FA6C-42ED-B595-5774AA31CFEAQ35856318-AFEEA2EA-3A03-4199-B6C5-125670FF361BQ35996079-68C3527C-27CD-4886-A01E-7111082831CFQ36043952-AAB598A9-9B68-43DA-BEF5-0288CE96B02DQ36228644-0DDADCC5-F956-4742-8B9C-ECD2296FCB5DQ36238065-2ABE1E55-BCC8-4DE8-AC38-192FAF4AAED7Q36260698-75C4473C-975F-48C6-AA05-813F2EECEB48Q36278041-C2F15DDC-E7E3-4F81-AFF6-49507A3BC898Q36295655-54E144C4-89B5-4440-998B-AF1322B85035Q36375092-F9261F08-C402-4D62-AF40-6C1E16725CE7Q36382791-F3D82A99-7727-4163-847F-92A033118329Q36384647-2D6D44D4-12D9-49ED-9FC2-5AF3AB6B4D8CQ36533403-8C4627EE-9E3E-4218-9740-F21080BE1F31Q36655805-75D16A9C-70F6-4DC5-9095-1348E60BF48AQ36717906-A852D522-81CB-44CD-9232-9A92654CB9EDQ36732679-B1E51F47-01E6-4DEE-B2D8-A20E76A7F599
P2860
The timing of TCR alpha expression critically influences T cell development and selection
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The timing of TCR alpha expression critically influences T cell development and selection
@ast
The timing of TCR alpha expression critically influences T cell development and selection
@en
type
label
The timing of TCR alpha expression critically influences T cell development and selection
@ast
The timing of TCR alpha expression critically influences T cell development and selection
@en
prefLabel
The timing of TCR alpha expression critically influences T cell development and selection
@ast
The timing of TCR alpha expression critically influences T cell development and selection
@en
P2860
P356
P1476
The timing of TCR alpha expression critically influences T cell development and selection
@en
P2093
Michelle M Sandau
Troy A Baldwin
P2860
P304
P356
10.1084/JEM.20050359
P407
P577
2005-07-01T00:00:00Z