Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. - Wikidata - awgldk - TriplyDB

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

http://www.wikidata.org/entity/Q35996079

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TGF-β: guardian of T cell function Lck availability during thymic selection determines the recognition specificity of the T cell repertoire B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.αβT cell receptors expressed by CD4(-)CD8αβ(-) intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities.Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage.Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction.Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Isolation, identification, and purification of murine thymic epithelial cells.TCR ITAM multiplicity is required for the generation of follicular helper T-cells.Thymic low affinity/avidity interaction selects natural Th1 cells Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer.Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency.Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.Hallmarks of Tissue-Resident Lymphocytes.Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.The RUNX complex: reaching beyond haematopoiesis into immunity.The checkpoint for agonist selection precedes conventional selection in human thymus.CD8αα intraepithelial lymphocytes arise from two main thymic precursors.Views on helper/cytotoxic lineage choice from a bottom-up approach.T-cell selection in the thymus: a spatial and temporal perspective.In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection.The Importance of Dendritic Cells in Maintaining Immune Tolerance.Dying to protect: cell death and the control of T-cell homeostasis.Cell death and thymic tolerance.Alternative Start Sites Downstream of Non-Sense Mutations Drive Antigen Presentation and Tolerance Induction to C-Terminal Epitopes.Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.Unusual selection and peripheral homeostasis for immunoregulatory CD4(-) CD8(-) T cells.Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.Skin-resident memory T cells keep herpes simplex virus at bay.Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

http://www.wikidata.org/entity/Q35996079

description

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2012年论文

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2012年论文

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2012年论文

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name

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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type

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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prefLabel

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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Nature Immunology

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

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Alfred Singer

http://www.w3.org/2001/XMLSchema#string

François Van Laethem

http://www.w3.org/2001/XMLSchema#string

Georgi S Angelov

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Jung-Hyun Park

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Leonid A Pobezinsky

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Lionel Feigenbaum

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Susanna Jeurling

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Xuguang Tai

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P2860

Essential role for ZAP-70 in both positive and negative selection of thymocytes

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

The biology of NKT cells

The fourth way? Harnessing aggressive tendencies in the thymus

Several different cell surface molecules control negative selection of medullary thymocytes

The timing of TCR alpha expression critically influences T cell development and selection

A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.

Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.

Positive and negative selection of T cells.

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569-578

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10.1038/NI.2292

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6

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13

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224868040

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1032395563

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22544394

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3362677

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