Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.
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Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces.Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells.Differences in the binding of transforming growth factor beta 1 to the acute-phase reactant and constitutively synthesized alpha-macroglobulins of rat.Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity.Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-ouProteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin.Chemical modification of alpha2-macroglobulin to generate derivatives that bind transforming growth factor-beta with increased affinity.Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region.alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis.Measurement of cytokines in clinical samples using immunoassays: problems and pitfalls.Design of growth factor sequestering biomaterialsMammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity.Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies.Safety of recombinant human platelet-derived growth factor-BB in Augment(®) Bone GraftEffects of growth factors and cytokines on osteoblast differentiation.Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Hepcidin bound to α2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels.Regulation of platelet-derived growth factor (PDGF) and alveolar macrophage-derived PDGF by alpha 2-macroglobulin.New strategies for treatment of pulmonary fibrosis.Inhibition of platelet-derived growth factor-BB-induced fibroblast proliferation by plasmin-activated alpha 2-macroglobulin is mediated via an alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein-dependent mechanism.Structural and functional analysis of the spontaneous re-formation of the thiol ester bond in human alpha 2-macroglobulin, rat alpha 1-inhibitor-3 and chemically modified derivatives.Identification of the high affinity binding site in transforming growth factor-beta involved in complex formation with alpha 2-macroglobulin. Implications regarding the molecular mechanisms of complex formation between alpha 2-macroglobulin and growPlatelet-derived growth factor-BB and basic fibroblast growth factor directly interact in vitro with high affinity.alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.Effect of implantation of Augment(®) Bone Graft on serum concentrations of platelet-derived growth factors: a pharmacokinetic study.Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons.Alpha(2) macroglobulin, a PSA binding protein, is expressed in human prostate stroma.Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.Differential Binding and Regulation of Platelet-derived Growth Factor A and B Chain Isoforms by α2-Macroglobulin
P2860
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P2860
Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.
description
1993 nî lūn-bûn
@nan
1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@ast
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@en
type
label
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@ast
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@en
prefLabel
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@ast
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@en
P2093
P2860
P356
P1433
P1476
Binding of platelet-derived gr ...... 2-macroglobulin conformations.
@en
P2093
K P Crookston
S L Gonias
P2860
P304
P356
10.1042/BJ2930443
P407
P478
293 ( Pt 2)
P577
1993-07-01T00:00:00Z