Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
about
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease statesDevelopment of calpain-specific inactivators by screening of positional scanning epoxide librariesInvolvement of calpains in adult neurogenesis: implications for stroke.Calcium-activated proteolysis as a therapeutic target in cerebrovascular disease.Folding transitions in calpain activator peptides studied by solution NMR spectroscopy.Neuroprotection with delayed calpain inhibition after transient forebrain ischemia.Proteases inhibition assessment on PC12 and NGF treated cells after oxygen and glucose deprivation reveals a distinct role for aspartyl proteases.Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation.Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.Ischemic neuronal cell death and organellae damage.Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model.All roads lead to disconnection?--Traumatic axonal injury revisited.Calpain is a mediator of preservation-reperfusion injury in rat liver transplantationCalpain-mediated signaling mechanisms in neuronal injury and neurodegenerationNeuroprotective strategies targeting apoptotic and necrotic cell death for stroke.Cerebral ischemic damage in diabetes: an inflammatory perspective.Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the ratThe calpain proteolytic system in neonatal hypoxic-ischemia.Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.Identification and characterization of PEBP as a calpain substrate.Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells--implications for neuroprotection against Ca-mediated excitotoxicity.Clinical potential for the use of neuroprotective agents. A brief overview.Beneficial effects of antecedent exercise training on limb motor function and calpain expression in a rat model of stroke.Calpain inhibitor A-558693 in experimental focal cerebral ischemia in rats.Concurrent assessment of calpain and caspase-3 activation after oxygen-glucose deprivation in primary septo-hippocampal cultures.Peptidyl alpha-keto amide inhibitor of calpain blocks excitotoxic damage without affecting signal transduction events.Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia.Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production.Protective effect of grape seed and skin extract on cerebral ischemia in rat: implication of transition metals.Calpain-2 as a therapeutic target for acute neuronal injury.Effects of calpain on sevoflurane-induced aged rats hippocampal neuronal apoptosis.Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia.Dual response of calpain to rat brain postdecapitative ischemia.Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95.Calpain activation and inhibition in organotypic rat hippocampal slice cultures deprived of oxygen and glucose.Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia.Species differences in fodrin proteolysis in the ischemic brain.
P2860
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P2860
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@ast
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@en
type
label
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@ast
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@en
prefLabel
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@ast
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@en
P2093
P356
P1433
P1476
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia.
@en
P2093
P304
P356
10.1161/01.STR.25.3.663
P407
P577
1994-03-01T00:00:00Z