Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. - Wikidata - awgldk - TriplyDB

Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor.

Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor.

http://www.wikidata.org/entity/Q30477161

about

Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.Cell motility through plasma membrane blebbing Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1 Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts Random versus directionally persistent cell migration Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin.Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.Rac1 regulates pancreatic islet morphogenesis Adenovirus-mediated genetic removal of signaling molecules in cultured primary mouse embryonic fibroblasts.Epithelial-specific knockout of the Rac1 gene leads to enamel defects.Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.SUMOylation of the GTPase Rac1 is required for optimal cell migration.Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1.Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation Microtubule-Mediated Inositol Lipid Signaling Plays Critical Roles in Regulation of Blebbing.A major role for Scar/WAVE-1 downstream of GPVI in platelets.Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism.Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1.ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing.DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway.Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio.Rac1 expression by fibroblasts is required for tissue repair in vivo.Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida.Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex.The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.Rapid screening for temperature-sensitive alleles in plants.

P2860

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P2860

Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor.

http://www.wikidata.org/entity/Q30477161

description

2006 nî lūn-bûn

@nan

2006 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մարտին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@ast

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@en

type

label

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@ast

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@en

prefLabel

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@ast

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@en

P1433

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P2860

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Q30477161-1CFF92E0-571D-4939-B40B-F7F492EC4F87

P356

MBC.E05-10-0955

P1433

Molecular Biology of the Cell

P1476

Rac1-null mouse embryonic fibr ...... latelet-derived growth factor.

@en

P2093

David J Kwiatkowski

http://www.w3.org/2001/XMLSchema#string

Feng Chen

http://www.w3.org/2001/XMLSchema#string

Gregor Cicchetti

http://www.w3.org/2001/XMLSchema#string

Luis Vidali

http://www.w3.org/2001/XMLSchema#string

Yasutaka Ohta

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of RAC3, a novel member of the Rho family

rac, a novel ras-related family of proteins that are botulinum toxin substrates

Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

Rho GTPases in cell biology

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor

The lamellipodium: where motility begins

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

P304

2377-2390

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P31

scholarly article

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10.1091/MBC.E05-10-0955

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5

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P478

17

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P577

2006-03-08T00:00:00Z

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P698

16525021

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P932

1446085

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