Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.
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Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formationPlk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cellsThe spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesisMyosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle.Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathwayThe 3Ms of central spindle assembly: microtubules, motors and MAPsThe final link: tapping the power of chemical genetics to connect the molecular and biologic functions of mitotic protein kinasesRecruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complexPolo-like kinase controls vertebrate spindle elongation and cytokinesisMultiple requirements of PLK1 during mouse oocyte maturationThe Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic ComplementationPolo-like kinase and its inhibitors: Ready for the match to start?Polo-like kinase 1 licenses CENP-A deposition at centromeresEstablishment of human papillomavirus infection requires cell cycle progressionDecoding Polo-like kinase 1 signaling along the kinetochore-centromere axisRole of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly.Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line.Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle.Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.Plk4 is required for cytokinesis and maintenance of chromosomal stability.Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex.Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis.Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesisSpatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells.Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.Role of senescence and mitotic catastrophe in cancer therapy.The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells.Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosisThe guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations.Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscissionA centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage.Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis.
P2860
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P2860
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.
description
2007 nî lūn-bûn
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2007 թուականի Մարտին հրատարակուած գիտական յօդուած
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2007 թվականի մարտին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
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name
Chemical genetics reveals the ...... ng cytokinesis in human cells.
@ast
Chemical genetics reveals the ...... ng cytokinesis in human cells.
@en
type
label
Chemical genetics reveals the ...... ng cytokinesis in human cells.
@ast
Chemical genetics reveals the ...... ng cytokinesis in human cells.
@en
prefLabel
Chemical genetics reveals the ...... ng cytokinesis in human cells.
@ast
Chemical genetics reveals the ...... ng cytokinesis in human cells.
@en
P2093
P2860
P356
P1476
Chemical genetics reveals the ...... ing cytokinesis in human cells
@en
P2093
Catherine L Randall
Chao Zhang
Kevan M Shokat
Prasad V Jallepalli
Robert P Fisher
P2860
P304
P356
10.1073/PNAS.0701140104
P407
P577
2007-03-06T00:00:00Z