Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging.
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Current advances in Phi29 pRNA biology and its application in drug deliveryStructure and assembly of the essential RNA ring component of a viral DNA packaging motorCrystal structure of 3WJ core revealing divalent ion-promoted thermostability and assembly of the Phi29 hexameric motor pRNADiscovery of a new motion mechanism of biomotors similar to the earth revolving around the sun without rotation.Construction of bacteriophage phi29 DNA packaging motor and its applications in nanotechnology and therapyGlobal structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling.Mechanism of one-way traffic of hexameric phi29 DNA packaging motor with four electropositive relaying layers facilitating antiparallel revolution.The ATPase of the phi29 DNA packaging motor is a member of the hexameric AAA+ superfamily.Revolution rather than rotation of AAA+ hexameric phi29 nanomotor for viral dsDNA packaging without coiling.Design and application of single fluorophore dual-view imaging system containing both the objective- and prism-type TIRF.Common mechanisms of DNA translocation motors in bacteria and viruses using one-way revolution mechanism without rotationDual-channel single-molecule fluorescence resonance energy transfer to establish distance parameters for RNA nanoparticles.Different sequences show similar quaternary interaction stabilities in prohead viral RNA self-assemblyPharmacological characterization of chemically synthesized monomeric phi29 pRNA nanoparticles for systemic delivery.Sequential action of ATPase, ATP, ADP, Pi and dsDNA in procapsid-free system to enlighten mechanism in viral dsDNA packaging.Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers.New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex.Biological Nanomotors with a Revolution, Linear, or Rotation Motion MechanismTwins, quadruplexes, and more: functional aspects of native and engineered RNA self-assembly in vivoThree-way junction conformation dictates self-association of phage packaging RNAsDevelopment of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism.Stable RNA nanoparticles as potential new generation drugs for cancer therapy.Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cellsUltrastable pRNA hexameric ring gearing hexameric phi29 DNA-packaging motor by revolving without rotating and coiling.Single molecule photobleaching (SMPB) technology for counting of RNA, DNA, protein and other molecules in nanoparticles and biological complexes by TIRF instrumentation.Three reversible and controllable discrete steps of channel gating of a viral DNA packaging motor.A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers.Assembly mechanism of the sixty-subunit nanoparticles via interaction of RNA with the reengineered protein connector of phi29 DNA-packaging motor.Finding of widespread viral and bacterial revolution dsDNA translocation motors distinct from rotation motors by channel chirality and sizeSingle-molecule imaging of the oligomer formation of the nonhexameric Escherichia coli UvrD helicase.Fabrication of massive sheets of single layer patterned arrays using lipid directed reengineered phi29 motor dodecamerOne-way traffic of a viral motor channel for double-stranded DNA translocationIncorporation of a viral DNA-packaging motor channel in lipid bilayers for real-time, single-molecule sensing of chemicals and double-stranded DNA.
P2860
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P2860
Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@ast
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@en
type
label
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@ast
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@en
prefLabel
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@ast
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@en
P2093
P2860
P356
P1476
Novel mechanism of hexamer rin ...... ed by single molecule imaging.
@en
P2093
P2860
P304
P356
10.1093/NAR/GKN669
P407
P577
2008-10-21T00:00:00Z