A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.
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Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxiaInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyMutations in TRPV4 cause Charcot-Marie-Tooth disease type 2CmGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons.Transient receptor potential channels as therapeutic targetsInhibition of diacylglycerol-sensitive TRPC channels by synthetic and natural steroidsChondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophyFunction and regulation of TRPP2 ion channel revealed by a gain-of-function mutantThe PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIPNew insights into behaviour using mouse ENU mutagenesisLight-dependent phosphorylation of the drosophila transient receptor potential ion channel.Transient receptor potential (TRP) channels: a clinical perspectiveA positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2TRPC channels and their implication in neurological diseasesmGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathwaysIn vivo evidence that TRAF4 is required for central nervous system myelin homeostasisLgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapsesNMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cellsEmerging roles of canonical TRP channels in neuronal function.Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein geneComputational neurobiology is a useful tool in translational neurology: the example of ataxiaCandidate screening of the TRPC3 gene in cerebellar ataxia.Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytesEctopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice.The role for alterations in neuronal activity in the pathogenesis of polyglutamine repeat disorders.The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxiasNna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.Insights from cerebellar transcriptomic analysis into the pathogenesis of ataxia.Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse.α-Synuclein expression in the mouse cerebellum is restricted to VGluT1 excitatory terminals and is enriched in unipolar brush cells.Consensus Paper: Cerebellar Development.Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death.Contribution of plasma membrane Ca ATPase to cerebellar synapse functionTRP channels.
P2860
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P2860
A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.
description
2009 nî lūn-bûn
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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@ast
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@en
type
label
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@ast
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@en
prefLabel
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@ast
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@en
P2093
P2860
P356
P1476
A point mutation in TRPC3 caus ...... lar ataxia in moonwalker mice.
@en
P2093
Andrea Hardy
Esther B E Becker
Francesca Achilli
Gareth T Banks
Kay E Davies
Maike D Glitsch
Peter L Oliver
P2860
P304
P356
10.1073/PNAS.0810599106
P407
P577
2009-04-07T00:00:00Z