Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.

Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.

Item
http://www.wikidata.org/entity/Q37381862
A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse.α-Synuclein expression in the mouse cerebellum is restricted to VGluT1 excitatory terminals and is enriched in unipolar brush cells.Consensus Paper: Cerebellar Development.The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.TRPC Channels: Prominent Candidates of Underlying Mechanism in Neuropsychiatric Diseases.TRPC3-dependent synaptic transmission in central mammalian neurons.Are Type 1 metabotropic glutamate receptors a viable therapeutic target for the treatment of cerebellar ataxia?Cellular and circuit mechanisms underlying spinocerebellar ataxias.Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and Purkinje cell dendritic development.Cerebellar modules operate at different frequencies.Commentary on "E. Mugnaini and A. Floris, the unipolar brush cell: a neglected neuron of the mammalian cerebellar cortex. J Comp Neurol, 339:174-180, 1994".Ion channel dysfunction in cerebellar ataxia.Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating
P2860

Early onset of ataxia in moonwalker mice is accompanied by complete ablation of type II unipolar brush cells and Purkinje cell dysfunction.

Item
http://www.wikidata.org/entity/Q37381862
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction.
@en
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction.
@nl
type
label
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction.
@en
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction.
@nl
prefLabel
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction.
@en
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Early onset of ataxia in moonw ...... and Purkinje cell dysfunction
@en
P2093
P2860
P304
P31
P356
10.1523/JNEUROSCI.2294-13.2013
P407
P433
P478
P50
P577
P698
P921
P932