The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
about
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's diseaseThe Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesisThe Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeletonAmyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal NeuronsAxonal transport and neurodegenerative disease: can we see the elephant?Differential release of β-amyloid from dendrite- versus axon-targeted APP.Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoDual-tagged amyloid-β precursor protein reveals distinct transport pathways of its N- and C-terminal fragmentsAmyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivoViewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages.Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ productionAccumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.Functional interaction between amyloid-β precursor protein and peripherin neurofilaments: a shared pathway leading to Alzheimer's disease and amyotrophic lateral sclerosis?Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanismsDeficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner.Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.A persistent stress response to impeded axonal transport leads to accumulation of amyloid-β in the endoplasmic reticulum, and is a probable cause of sporadic Alzheimer's disease.Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules.HSV, axonal transport and Alzheimer's disease: in vitro and in vivo evidence for causal relationships.Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migrationIncreased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer's disease neurons.UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.Basic mechanisms of neurodegeneration: a critical update.Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing.Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?Imaging the Intracellular Trafficking of APP with Photoactivatable GFP.Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia.Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease.
P2860
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P2860
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The cleavage products of amylo ...... y transported within neurites.
@ast
The cleavage products of amylo ...... y transported within neurites.
@en
type
label
The cleavage products of amylo ...... y transported within neurites.
@ast
The cleavage products of amylo ...... y transported within neurites.
@en
prefLabel
The cleavage products of amylo ...... y transported within neurites.
@ast
The cleavage products of amylo ...... y transported within neurites.
@en
P2093
P2860
P1476
The cleavage products of amylo ...... ly transported within neurites
@en
P2093
Bruce T Lamb
Virgil Muresan
Zoia Muresan
P2860
P304
P356
10.1523/JNEUROSCI.2558-08.2009
P407
P577
2009-03-01T00:00:00Z