SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. - Wikidata - awgldk - TriplyDB

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

http://www.wikidata.org/entity/Q30488841

about

Dynamic Regulation of TCR-Microclusters and the Microsynapse for T Cell Activation Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy The Dendritic Cell Synapse: A Life Dedicated to T Cell Activation Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1)Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.Role for ADAP in shear flow-induced platelet mechanotransduction.Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate Development of a prognostic model for breast cancer survival in an open challenge environment.KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells.Biomolecular events in cancer revealed by attractor metagenes.Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression.The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.Serum biomarkers VEGF-C and IL-6 are associated with severe human Peripheral Artery Stenosis.Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins.Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells The LAT story: a tale of cooperativity, coordination, and choreography.Integrin signalling and function in immune cells.Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons.SKAP1 is dispensable for chemokine-induced migration of primary T-cells LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1.G-CSF inhibits LFA-1-mediated CD4+ T cell functions by inhibiting Lck and ZAP-70.The adapter protein ADAP is required for selected dendritic cell functions.

P2860

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P2860

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

http://www.wikidata.org/entity/Q30488841

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@ast

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@en

type

label

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@ast

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@en

prefLabel

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@ast

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@en

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PNAS.0900510106

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Proceedings of the National Academy of Sciences of the United States of America

P1476

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

@en

P2093

Bin Wei

http://www.w3.org/2001/XMLSchema#string

Christopher E Rudd

http://www.w3.org/2001/XMLSchema#string

Georges Bismuth

http://www.w3.org/2001/XMLSchema#string

Hongyan Wang

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P2860

FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells

Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2

An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R

The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production

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12436-12441

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10.1073/PNAS.0900510106

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P433

30

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106

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2009-07-15T00:00:00Z

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26681309

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19617540

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2710989

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