INF2 is an endoplasmic reticulum-associated formin protein.
about
Mutations in the formin gene INF2 cause focal segmental glomerulosclerosisAn actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2Formins and microtubulesFormins at a glanceThe Bacterial Effector VopL Organizes Actin into Filament-like StructuresA nucleator arms race: cellular control of actin assemblyFormins and membranes: anchoring cortical actin to the cell wall and beyond.ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arraysCalcium-mediated actin reset (CaAR) mediates acute cell adaptationsThrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease.Mitochondrial fission: rings around the organelle.Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture.The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed endsINF2-mediated severing through actin filament encirclement and disruption.Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.Novel roles for actin in mitochondrial fissionInverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assemblyMechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains.Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2)New mechanisms and functions of actin nucleationTransient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission.Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rimAssembly and turnover of short actin filaments by the formin INF2 and profilinA mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division.Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains.Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing.Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosisInverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction.Actin filament nucleation and elongation factors--structure-function relationships.Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton.Educational paper: the podocytopathies.Structural features and interfacial properties of WH2, β-thymosin domains and other intrinsically disordered domains in the regulation of actin cytoskeleton dynamics.Formins: linking cytoskeleton and endomembranes in plant cells.Neuropathologic characterization of INF2-related Charcot-Marie-Tooth disease: evidence for a Schwann cell actinopathy.Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
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P2860
INF2 is an endoplasmic reticulum-associated formin protein.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
INF2 is an endoplasmic reticulum-associated formin protein.
@ast
INF2 is an endoplasmic reticulum-associated formin protein.
@en
type
label
INF2 is an endoplasmic reticulum-associated formin protein.
@ast
INF2 is an endoplasmic reticulum-associated formin protein.
@en
prefLabel
INF2 is an endoplasmic reticulum-associated formin protein.
@ast
INF2 is an endoplasmic reticulum-associated formin protein.
@en
P2860
P356
P1476
INF2 is an endoplasmic reticulum-associated formin protein
@en
P2093
Ekta Seth Chhabra
Vinay Ramabhadran
P2860
P304
P356
10.1242/JCS.040691
P407
P577
2009-04-14T00:00:00Z