Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.
about
The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignmentCLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelityRegulation of kinetochore-microtubule attachments through homeostatic control during mitosisReconstituting the kinetochore–microtubule interface: what, why, and how+TIPs: SxIPping along microtubule endsTPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila OocytesMitotic kinesin CENP-E promotes microtubule plus-end elongation.Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).Modulation of Golgi-associated microtubule nucleation throughout the cell cycleKinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends.Finding the middle ground: how kinetochores power chromosome congression.Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores.A genomic toolkit to investigate kinesin and myosin motor function in cells.CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.Length-dependent anisotropic scaling of spindle shapeSeptin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epitheliaKinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachmentsChromosomes and cancer cells.Mechanisms of chromosomal instability.Mechanisms of Chromosome Congression during Mitosis.Anaphase A: Disassembling Microtubules Move Chromosomes toward Spindle Poles.Prevention and correction mechanisms behind anaphase synchrony: implications for the genesis of aneuploidy.Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.Shaping microtubules into diverse patterns: molecular connections for setting up both ends.Kinetochores and disease: keeping microtubule dynamics in check!Regulatory mechanisms of kinetochore-microtubule interaction in mitosis.Maturation of the kinetochore-microtubule interface and the meaning of metaphase.Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.The molecular basis for kinesin functional specificity during mitosis.GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.The CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein.Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules.CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development.CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
P2860
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P2860
Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Motor-independent targeting of ...... le turnover and poleward flux.
@ast
Motor-independent targeting of ...... le turnover and poleward flux.
@en
type
label
Motor-independent targeting of ...... le turnover and poleward flux.
@ast
Motor-independent targeting of ...... le turnover and poleward flux.
@en
prefLabel
Motor-independent targeting of ...... le turnover and poleward flux.
@ast
Motor-independent targeting of ...... le turnover and poleward flux.
@en
P2093
P2860
P50
P1433
P1476
Motor-independent targeting of ...... ule turnover and poleward flux
@en
P2093
Amity L Manning
Ana R R Maia
Andrej Shevchenko
Anthony Hyman
John R Yates
Niels Galjart
Stefano Maffini
Zoltan Maliga
P2860
P304
P356
10.1016/J.CUB.2009.07.059
P407
P577
2009-09-03T00:00:00Z