Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. - Wikidata - awgldk - TriplyDB

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.

http://www.wikidata.org/entity/Q30491620

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Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction Role of kappa-opioid receptors in stress and anxiety-related behavior.Drug withdrawal conceptualized as a stressor.Stress and VTA synapses: implications for addiction and depression Opioid receptors: toward separation of analgesic from undesirable effects The multiple facets of opioid receptor function: implications for addiction Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors.The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors The development and maintenance of drug addiction 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking.Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms 6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment.Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening.Identification of novel functionally selective κ-opioid receptor scaffolds.Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction Poststress block of kappa opioid receptors rescues long-term potentiation of inhibitory synapses and prevents reinstatement of cocaine seeking.The kappa opioid receptor: from addiction to depression, and back.Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A The effects of morphine, naloxone, and κ opioid manipulation on endocrine functioning and social behavior in monogamous titi monkeys (Callicebus cupreus).Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction.The dark side of emotion: the addiction perspective Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity.Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment.Early role of the κ opioid receptor in ethanol-induced reinforcement Morphine history sensitizes postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.

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P2860

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.

http://www.wikidata.org/entity/Q30491620

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2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Activation of the kappa opioid ...... s and reinstates drug seeking.

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Activation of the kappa opioid ...... s and reinstates drug seeking.

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Activation of the kappa opioid ...... s and reinstates drug seeking.

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Activation of the kappa opioid ...... s and reinstates drug seeking.

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Activation of the kappa opioid ...... s and reinstates drug seeking.

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Activation of the kappa opioid ...... s and reinstates drug seeking.

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Benjamin B Land

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Charles Chavkin

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Daniel Messinger

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Megumi Aita

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Michael R Bruchas

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Selena Schattauer

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William J Giardino

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P2860

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons

Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

A role for brain stress systems in addiction.

The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system

Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria.

The molecular neurobiology of depression

Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase

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19168-19173

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