Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
about
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometryEfficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanismsTransient Protein States in Designing Inhibitors of the MDM2-p53 InteractionSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsAdaptability in protein structures: structural dynamics and implications in ligand design.Towards a career in bioinformaticsStructure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.Anchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein.A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations.Molecular dynamic simulation insights into the normal state and restoration of p53 function.On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.Protein-peptide association kinetics beyond the seconds timescale from atomistic simulationsWhy is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.Co-operative intra-protein structural response due to protein-protein complexation revealed through thermodynamic quantification: study of MDM2-p53 binding.Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99.Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53.
P2860
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P2860
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@ast
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@en
type
label
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@ast
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@en
prefLabel
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@ast
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@en
P2860
P1433
P1476
Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
@en
P2093
Chandra S Verma
Shubhra Ghosh Dastidar
P2860
P2888
P356
10.1186/1471-2105-10-S15-S6
P478
10 Suppl 15
P50
P577
2009-12-03T00:00:00Z
P5875
P6179
1014307513