Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. - Wikidata - awgldk - TriplyDB

Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.

Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.

http://www.wikidata.org/entity/Q30492556

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The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease Linkage between the mechanisms of thrombocytopenia and thrombopoiesis Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study.In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network.Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells In vivo real-time two-photon microscopic imaging of platelet aggregation induced by selective laser irradiation to the endothelium created in the beta-actin-green fluorescent protein transgenic mice.Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.Recent findings in the genetics of blood pressure and hypertension traits.The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions.Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3 Visualization of in vivo thromboprophylactic and thrombolytic efficacy of enoxaparin in laser-induced vascular endothelial injury model using multiphoton microscopy Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy.TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets Platelets as cellular effectors of inflammation in vascular diseases.Genetics of atherothrombosis and thrombophilia.Factor XIII is a key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Role of the adaptor protein LNK in normal and malignant hematopoiesis.Shared genetic aetiology of coronary artery disease and atherosclerotic stroke - 2015.Integrin αIIbβ3 outside-in signaling.The function of SH2B3 (LNK) in the kidney.The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders.LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection.Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells.Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium

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P2860

Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.

http://www.wikidata.org/entity/Q30492556

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

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2009年论文

@wuu

name

Lnk regulates integrin alphaII ...... thrombus development in vivo.

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Lnk regulates integrin alphaII ...... thrombus development in vivo.

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type

label

Lnk regulates integrin alphaII ...... thrombus development in vivo.

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Lnk regulates integrin alphaII ...... thrombus development in vivo.

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prefLabel

Lnk regulates integrin alphaII ...... thrombus development in vivo.

@ast

Lnk regulates integrin alphaII ...... thrombus development in vivo.

@en

P1433

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Journal of Clinical Investigation

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Lnk regulates integrin alphaII ...... thrombus development in vivo.

@en

P2093

Akira Sawaguchi

http://www.w3.org/2001/XMLSchema#string

Atsushi Oda

http://www.w3.org/2001/XMLSchema#string

Hidekazu Nishikii

http://www.w3.org/2001/XMLSchema#string

Hiromitsu Nakauchi

http://www.w3.org/2001/XMLSchema#string

Ichiro Manabe

http://www.w3.org/2001/XMLSchema#string

Kiyoshi Takatsu

http://www.w3.org/2001/XMLSchema#string

Koji Eto

http://www.w3.org/2001/XMLSchema#string

Naoya Takayama

http://www.w3.org/2001/XMLSchema#string

Noriko Tamura

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Satoshi Nishimura

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P2860

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

Src kinase activation by direct interaction with the integrin beta cytoplasmic domain

PTP-1B is an essential positive regulator of platelet integrin signaling

Newly identified genetic risk variants for celiac disease related to the immune response

Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo

Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets

Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk

The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways

Integrins: dynamic scaffolds for adhesion and signaling in platelets

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

P304

179-190

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scholarly article

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10.1172/JCI39503

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P433

1

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120

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Hitoshi Takizawa

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2009-12-21T00:00:00Z

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20038804

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2798683

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