Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

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Q42582678

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Podoplanin associates with adverse postoperative prognosis of patients with clear cell renal cell carcinoma A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics Platelet signaling Lymph flow regulates collecting lymphatic vessel maturation in vivo.New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2 Podoplanin: emerging functions in development, the immune system, and cancer Identification of platelet function defects by multi-parameter assessment of thrombus formation Targeting a novel domain in podoplanin for inhibiting platelet-mediated tumor metastasis CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.Platelet ITAM signaling is critical for vascular integrity in inflammation.Vascular tumours in infants. Part II: vascular tumours of intermediate malignancy [corrected] and malignant tumours.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.The role of RNA interference in the developmental separation of blood and lymphatic vasculature Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk.CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP ProxTom lymphatic vessel reporter mice reveal Prox1 expression in the adrenal medulla, megakaryocytes, and platelets CLEC-2 expression is maintained on activated platelets and on platelet microparticles.Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.Historical perspective and future directions in platelet research.Lymphatic vascular morphogenesis in development, physiology, and disease Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.How platelets safeguard vascular integrity.Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Signaling by myeloid C-type lectin receptors in immunity and homeostasis Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.The new era of the lymphatic system: no longer secondary to the blood vascular system Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization.Microfluidic assessment of functional culture-derived platelets in human thrombi under flow.Molecular regulation of lymphangiogenesis in development and tumor microenvironment.CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets.Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.

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P2860

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

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Essential in vivo roles of the ...... of CLEC-2-deficient platelets.

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Guo Ding

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Hirokazu Kashiwagi

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Katsue Suzuki-Inoue

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Kazuo Umemura

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Kazuya Hokamura

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Koji Eto

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Masanori Hirashima

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Osamu Inoue

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Satoshi Nishimura

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Yonchol Shin

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P2860

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors

Platelet-collagen interaction: is GPVI the central receptor?

Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen

Dual function of C-type lectin-like receptors in the immune system

Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis

T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

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10.1074/JBC.M110.130575

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English

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Y Yatomi

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Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

about

P2860

P2860

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

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