11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.
about
Local amplification of glucocorticoids in the aging brain and impaired spatial memoryAging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognitionBrain mineralocorticoid receptors in cognition and cardiovascular homeostasisModulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammationNeuroinflammation in the normal aging hippocampusHPA axis responsiveness to stress: implications for healthy aging.Posterior parietal cortex and long-term memory: some data from laboratory animals.Stress response and child health.11β-Hydroxysteroid dehydrogenase activity in the brain does not contribute to systemic interconversion of cortisol and cortisone in healthy men.Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.The multifaceted mineralocorticoid receptorCognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease.11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects.Prenatal alcohol exposure is associated with altered subcellular distribution of glucocorticoid and mineralocorticoid receptors in the adolescent mouse hippocampal formation.Vitamin A status regulates glucocorticoid availability in Wistar rats: consequences on cognitive functions and hippocampal neurogenesis?Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory.11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline.Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery.The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related change.Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged miceClinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults.Forebrain-Specific Transgene Rescue of 11β-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11β-HSD1 Deficient Mice.Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged miceDecreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice.Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice.Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice.11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids.Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression.Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats.Behavioral tagging and capture: long-term memory decline in middle-aged rats.
P2860
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P2860
11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@ast
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@en
type
label
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@ast
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@en
prefLabel
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@ast
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@en
P2093
P2860
P1476
11beta-hydroxysteroid dehydrog ...... and causes memory impairments.
@en
P2093
Janice M Paterson
John J Mullins
Jonathan R Seckl
Joyce L W Yau
June Noble
Megan C Holmes
Roderick N Carter
Shruti Chitnis
P2860
P304
P356
10.1523/JNEUROSCI.0731-10.2010
P407
P577
2010-05-01T00:00:00Z